Hypolipidemic and Hepatoprotective Effects of Linum usitatissimum L. Seeds on Hypercholesterolemic Rats | Chapter 1 | Current Overview on Pharmaceutical Science Vol. 6

 Hyperlipidaemia is a never-ending, liberal affliction characterised by a assortment of hereditary and seized environments that influence unusually inflated lipid levels in persons. Several preclinical and dispassionate studies have proved that abstinence from food supplementation accompanying Linum Usitatissimum has advantageous cardiovascular belongings to a degree antihypertensive operation, antiatherogenic belongings, cholesterol threatening, antagonistic-angering operation, and arrhythmia restriction. Few studies have happened transported on the hepatoprotective belongings of beat sources in hyperlipidemic animal models. This study was launched to judge the hypolipidemic and hepatoprotective effect of Linum sources. The study was completed activity during of two months in Department of Pharmacology KIMS, Bhubaneswar. A total of 36 Albino wistar rats were calm and detached into six groups of six rats each. Group II was hypercholesterolemic (HC) control, Group III was situation control and Group IV to VI rats were likely various doses of extract. At the end of two months, skilled is a important decrease in lipid limits and liver enzymes fully three groups taking the extract, place the maximal application of extract secondhand is corresponding to the standard drug. This study decides that accumulating flaxseeds to the diet can lessen the rise in flowing cholesterol levels produced by a extreme cholesterol diet on account of their content of alfa-linolenic acid (ALA) and lignins. This study further demonstrated that flaxseed has a hepatoprotective part in hypercholesterolaemia.

Author(s) Details:

Chaitali Pattanayak,
Department of Pharmacology, Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed to be University, Bhubaneswar, India.

Jyotirmayee Bahinipati,
Department of Biochemistry, Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed to be University, Bhubaneswar, India.

Vartika Srivastava,
Department of Pharmacology, Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed to be University, Bhubaneswar, India.

Sougata Sarkar,
DM Clinical Pharmacology, Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, India.

Please see the link here: https://stm.bookpi.org/COPS-V6/article/view/9459

Determining the Role of the Ethanolic Leaf Extract of Diodia sarmentosa as a Free Radical Scavenger, and an Antioxidant in High Fat Diet Fed Wistar Rats | Chapter 12 | New Visions in Biological Science Vol. 5

 Diodia sarmentosa (Sw) is a straggling or procumbent perennial herb that grows in evergreen forest, riverine vegetation, and bushland. It has been traditionally used to cure a variety of diseases, including ulcers and diabetes. The role of Diodia sarmentosa ethanolic leaf extract as a free radical scavenger and antioxidant in high fat diet-fed wistar rats was examined in this study. The researchers want to see if the plant extract can scavenge free radicals in vitro and if it may improve antioxidant activity and minimise lipid peroxidation in vivo. Thirty (30) male wistar rats (150 g-200 g) were divided into five (5) groups: negative control rats, positive control rats, low dose extract rats treated with 250 mg/kg, high dose extract rats treated with 500 mg/kg of the extract, and standard antihyperlipidaemic drug rats treated with 5 mg/kg of Simvastatin in this study. For six (6) weeks, the rats were fed a high-fat diet containing Ghee and Coconut oil in a 3:1 ratio, and treatments began after the third week and continued until the sixth week. The role of Diodia sarmentosa as a free radical scavenger and antioxidant was determined by measuring nitric oxide radical, hydroxyl radical, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione S-transferase (GST) in the test rats' serum. In vitro, Diodia sarmentosa scavenged free radicals by blocking nitric oxide and hydroxyl radicals in a concentration-dependent manner, resulting in IC50 values of 907.17 g/ml 45.36 and 2173.44 g/ml 100.11, respectively. When compared to the PC group, antioxidant enzymes such as SOD, GPx, and CAT in the test rats' serum were significantly elevated (p0.05) by both doses of the extract, and its effect was similar to that of the standard medicine (Simvastatin). Both doses of the extract reduced GST activity in the test rats' serum, although the difference was not statistically significant (p>0.05). Finally, both doses of the extract in the serum of the test rats considerably reduced the measure of lipid peroxidation, i.e. malondialdehyde level (p0.05). To summarise, Diodia sarmentosa possesses antioxidant properties due to its ability to scavenge free radicals, replenish antioxidant enzymes, and minimise lipid peroxidation.

Author(S) Details

Stephen Chinedumije Korie
Department of Biotechnology, Federal University of Technology, Owerri, Nigeria.

Tobias I. Ndubuisi Ezejiofor
Department of Biotechnology, Federal University of Technology, Owerri, Nigeria.

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Scientific Investigation of Borreria hispida (Linn) – A Tamil Traditional Medicinal Plant against Hyperlipidemia Disease | Chapter 13 | Challenges and Advances in Chemical Science Vol. 3

 The goal of this study was to see how different extracts of the whole plant of Borreria hispida (Linn) affected lipid levels in high-fat rats. Borreria hispida (Linn) dry powder was extracted using a Soxhlet extractor with various solvents (PE, EA, and methanol), and the crude various extract was used for hypolipidemic activities. All of the extracts were confirmed to be safe up to 2000mg/kg in the acute toxicity investigation, hence one hundredth of this dose was used as the assessment dose. Borreria hispida (Linn) extracts (Petroleum ether, Ethyl acetate, and Methanol) were given to rats fed a high-fat diet at a dose of 200mg/kg/day to see if they may help lower cholesterol levels. Six groups of six animals were formed from a total of 36 animals. Group I was normal, Group II was a high-fat diet, Group III was a high-fat diet plus pet.ether extract (200 mg/kg b.wt), Group IV was a high-fat diet plus ethyl acetate extract (200 mg/kg b.wt), Group V was a high-fat diet plus methanol extract (200 mg/kg b.wt), and Group VI was a high-fat diet plus atorvastatin (1.2) The HFD fed group had a noticeable rise in body weight (p0.001), which was reduced by the administration of Borreria hispida methanolic extract (200 mg/kg). Total cholesterol, triglycerides, phospholipids, LDL-C, and VLDL-C levels were all higher in rats on a high-fat diet (group II). When compared to HFD rats, rats treated with a methanolic extract of Borreria hispida (200mg/kg/day) showed a substantial (p0.001) decrease in body weight, plasma and tissue total cholesterol, triglycerides, phospholipids, plasma LDL-C and VLDL-C, as well as an increase in plasma HDL-C. (group II). The other two extract treatment groups did not provide similar results. Borreria hispida methanolic extract may protect against atherosclerosis and lower the atherogenic index compared to other extract treatment groups. This discovery gives some biochemical evidence for the use of a methanolic extract of the whole plant of Borreria hispida to prevent atherosclerosis and lower the atherogenic index, consequently bolstering the use of Borreria hispida in the management of atherosclerosis on a local level.

Author (S) Details

C. D. Shaji Selvin
St. John’s College of Pharmaceutical Science and Research, Kattappana South Post, Idukki Dist, Keralar- 685515, India.

Jambula Dinesh Babu
Department of Pharmacology, Scient Institute of Pharmacy, Ibrahimpatnam, Mandal, Ranga reddy Dist, Telangana-501 506, India.

A. Kottai Muthu
Department of Pharmacy, Annamalai University, Annamalai Nagar-608 002, Chidambaram, Tamilnadu, India.

View Book :- https://stm.bookpi.org/CACS-V3/article/view/2959