A Retrospective Study on Clinical Profile of Stroke in Young and Elderly between 2012-2013 in GMERS Medical College and Hospital, Gandhinagar, Gujarat | Chapter 11 | Advancement and New Understanding in Medical Science Vol. 9

Aim: The present study was conducted know the difference in clinical profile in young and elderly stroke patients, by knowing this we can help young physicians to combat this deadly and disabling disease in effective manner.

Background: Stroke is a devastating and disabling cerebrovascular disease with significant amount of residual deficit leading on to economic loss. The cerebrovascular stroke is one of the leading causes of morbidity & mortality in adult life. Indian studies have shown a stroke prevalence of 471.58/100000 population. Stroke mostly occurs in elderly people. Risk factors for stroke differ between young and elderly patients.

Methods: This is a retrospective study of all new patients managed for stroke in the medical ward of GMERS medical college and hospital, Gandhinagar, Gujarat from January1, 2012 to December 31, 2013. We studied difference in clinical presentation, risk factors, neurological presentation, pattern of brain strokes, areas of brain affected as per CT scan findings in both the groups GMERS medical college and hospital Gandhinagar.

Results: Incidence of stroke in elderly (≥45 years) was higher than young (<45 years) patients with male predominance in both the groups. Most common clinical presentation from both age groups was hemiplegia (75% in young vs. 72.1% in elderly). Common risk factors in were Hypertension and past h/o Cerebrovascular disease (25%) and smoking (16.6%) in young and Hyepertension T (37.1%), dyslipidemia and smoking (14.3%) in elderly. Most common type of stroke in both age groups was ischemic (83.3% in young vs. 73.2% in elderly), followed by Hemorrhagic. Common sites of hemorrhage in young and elderly were lobar and thalamoganglionic. Most common infarction site in both age groups is MCA territory.

Conclusion: The cerebrovascular stroke was more in elderly with hypertension and smoking was the most common risk factor in both age groups and most common type was ischemic. Most common site of hemorrhage in elderly was thalamoganglionic followed by lobar. Most common site of infarct in both age groups was area supplied by middle cerebral artery. More research is required to address stroke pattern in young and elderly to combat this deadly and disabling disease.

Author(s) Details:

Chirayu V. Vaidya,
Department of Medicine, Nootan Medical College & Research Center, Visnagar 384315, Gujarat, India.

Drusty K. Majmudar,
Department of Radiodiagnosis, NHL Medical College, Shardaben Hospital, Saraspur, Ahmedabad-380018, Gujarat, India.

Please see the link here: https://stm.bookpi.org/ANUMS-V9/article/view/13635

Hypolipidemic and Hepatoprotective Effects of Linum usitatissimum L. Seeds on Hypercholesterolemic Rats | Chapter 1 | Current Overview on Pharmaceutical Science Vol. 6

 Hyperlipidaemia is a never-ending, liberal affliction characterised by a assortment of hereditary and seized environments that influence unusually inflated lipid levels in persons. Several preclinical and dispassionate studies have proved that abstinence from food supplementation accompanying Linum Usitatissimum has advantageous cardiovascular belongings to a degree antihypertensive operation, antiatherogenic belongings, cholesterol threatening, antagonistic-angering operation, and arrhythmia restriction. Few studies have happened transported on the hepatoprotective belongings of beat sources in hyperlipidemic animal models. This study was launched to judge the hypolipidemic and hepatoprotective effect of Linum sources. The study was completed activity during of two months in Department of Pharmacology KIMS, Bhubaneswar. A total of 36 Albino wistar rats were calm and detached into six groups of six rats each. Group II was hypercholesterolemic (HC) control, Group III was situation control and Group IV to VI rats were likely various doses of extract. At the end of two months, skilled is a important decrease in lipid limits and liver enzymes fully three groups taking the extract, place the maximal application of extract secondhand is corresponding to the standard drug. This study decides that accumulating flaxseeds to the diet can lessen the rise in flowing cholesterol levels produced by a extreme cholesterol diet on account of their content of alfa-linolenic acid (ALA) and lignins. This study further demonstrated that flaxseed has a hepatoprotective part in hypercholesterolaemia.

Author(s) Details:

Chaitali Pattanayak,
Department of Pharmacology, Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed to be University, Bhubaneswar, India.

Jyotirmayee Bahinipati,
Department of Biochemistry, Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed to be University, Bhubaneswar, India.

Vartika Srivastava,
Department of Pharmacology, Kalinga Institute of Medical Sciences (KIMS), KIIT Deemed to be University, Bhubaneswar, India.

Sougata Sarkar,
DM Clinical Pharmacology, Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, India.

Please see the link here: https://stm.bookpi.org/COPS-V6/article/view/9459

Determining the Effects of Methanolic Extracts of Quisqualis indica on Passive Smoking Induced Hyperlipidemia in Rats| Chapter 1 | Challenges and Advances in Pharmaceutical Research Vol.3

The hypolipidemic effect of methanolic and aqueous extracts of aerial portions of Quisqualis indica (QI), mostly flowers, on passive smoking (PS) induced hyperlipidemia in rats will be compared in this study. Hyperlipidemia was generated by passive smoking in a closed room with one burning cigarette inside. After treatment with the reagent contained in the auto span diagnostic kit, the hypolipidemic activity was assessed by detecting the amount of blood serum in UV at 505 nm. A dosage of Methanolic and aqueous extracts of QI was generated using distilled water, i.e. 100 mg/kg p.o. At varying concentrations and dosages, both QI extracts significantly reduce the hazardous lipid layer in blood serum. This indicates that the plant possesses hypolipidemic properties. It significantly reduces LDL, VLDL, cholesterol, triglycerides, and elevates HDL levels in blood serum, which might be due to the plants' antioxidants suppressing lipid peroxidation. Our findings suggest that methanolic plant extracts are superior than aqueous extracts in terms of reducing harmful lipids and restoring lipid metabolism abnormalities in hyperlipidemic patients.

Author(s) Details:

Jyoti Sahu,
Bharat Institute of Technology, Ibrahimpatnam and Siddhi Vinayak Institute of Technology, Bilaspur, Chhattisgarh, India.

Pushpendra Kumar Patel,
Bharat Institute of Technology, Ibrahimpatnam and Siddhi Vinayak Institute of Technology, Bilaspur, Chhattisgarh, India.

Please see the link here: https://stm.bookpi.org/CAPRV-3/article/view/6941

Determining the Effect of Curry Leaves and Cucumber Fruit on Lipid Profile in Menopausal Women with Hyperlipidaemia | Chapter 08 | Emerging Trends in Disease and Health Research Vol. 6

 Hyperlipidemia increases the chances of acquiring cardiovascular disease (CVD). Total cholesterol (TC) and triacyl glycerol (TAG) levels in the blood are elevated in hyperlipidaemia. The purpose of this study was to see how curry leaves powder and slicing cucumber fruit affected hyperlipidemia in menopausal women living in rural areas.

Methods: Thirty menopausal healthy women from rural communities (45–65 years old) with mild hyperlipidemia were randomly assigned to one of two groups: control or experimental. The control group received no treatment while the experimental group received cucumber (100-125 g) and curry leaves powder (5 g) once daily for 45 days. A questionnaire was used to collect the demographic information. Fasting blood samples were taken before and after the intervention to assess total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triacyl glycerol levels (TAG).

TC, LDL-C, and TAG were significantly (p0.05) reduced in the curry leaves powder and cucumber treatment groups. Only the curry leaves powder treatment group had a significantly (p0.05) higher HDL-C level (46.19.2 mg/dl) (average 12 percent). Although the control group's TC, LDL-C, and TAG mean levels were higher, the difference was not statistically significant. When the efficacy of the test chemicals at the tested doses was compared, the HDL-C level in the curry leaves treated group was statistically higher (p =0.09).

Conclusions: In menopausal women with hyperlipidemia, curry leaves and cucumber were successful in boosting HDL-C and decreasing LDL-C and TAG levels, indicating a possible neutraceutical role in CVD treatment.

Author(S) Details

John Molly
Department of Research, Saveetha University, Chennai-603 105, Tamil Nadu, India and Department of Community Health, Amala College of Nursing, Amala Nagar, Thrissur- 680 555, Kerala, India.

Silvia Edison
Department of Medical and Surgical Nursing, Al Shifa College of Nursing, Angadippuram, Malappuram- 679 321, Kerala, India.

R. Vijayaraghavan
Department of Research, Saveetha University, Chennai-603 105, Tamil Nadu, India.

Thekuttuparambil Ananthanarayanan Ajith
Department of Biochemistry, Amala College of Nursing, Amala Nagar, Thrissur- 680 555, Kerala, India.

View Book:- https://stm.bookpi.org/ETDHR-V6/article/view/6420