Exploring the Plant Based Extracts for Treatment of Diabetic Caused by Steroids | Chapter 9 | Current Overview on Pharmaceutical Science Vol. 8

 The present study was judge the hypoglycemic and hypolipidemic effect of ethyl acetate (EAEPC) and ethanolic (EEPC) extracts from fruits of Pyrus communis by dexamethasone-inferred diabetic rats. Chronic hyperglycemia during diabetes causes glycation of corpse proteins that in turn leads to subordinate complications moving eyes, kidneys, nerves and arteries. The various groups of animals were inferred for diabetes with dexamethasone (10 mg/kg bw- sc) during the day for 11 days except normal control. The extracts 200mg/kg and glibenclamide 5mg/kg was executed to treat the diabetic rats once daily for 11 days. When distinguished to the diabetic control, the treated groups illustrated significant (p<0.01) antagonistic-diabetic and hypolipidemic activity. The extracts have the alike beneficial belongings on blood glucose levels as the standard. Additionally, it upholds body weight while threatening elevated levels of triglycerides (TGL), depressed density lipoproteins (LDL), very reduced density lipoproteins (VLDL), and total cholesterol (TC). It likewise increases low levels of extreme density lipoprotein (HDL). We got near the conclusion that two together extracts had the potential to be persuasive oral hypoglycemic cures and showed promise for the production of phytomedicines for diabetes mellitus and its complications.

Author(s) Details:

C. Velmurugan,
Department of Pharmacology, PGP College of Pharmaceutical Science and Research Institute, Namakkal-637207. Affiliated to The Tamilnadu Dr M.G.R Medical University, Chennai, Tamilnadu-600032, India.

Sujith Thomas,
Department of Pharmacology, Moulana College of Pharmacy, Affiliated to Kerala University of Health Sciences, Thrissur, Kerala-680596, India.

S. Venkatesh,
Department of Pharmacology, National College of Pharmacy, Kerala-673602. Affiliated to Kerala University of Health Sciences, Thrissur, Kerala-680596, India.

Please see the link here: https://stm.bookpi.org/COPS-V8/article/view/9868

Determining the Effects of Methanolic Extracts of Quisqualis indica on Passive Smoking Induced Hyperlipidemia in Rats| Chapter 1 | Challenges and Advances in Pharmaceutical Research Vol.3

The hypolipidemic effect of methanolic and aqueous extracts of aerial portions of Quisqualis indica (QI), mostly flowers, on passive smoking (PS) induced hyperlipidemia in rats will be compared in this study. Hyperlipidemia was generated by passive smoking in a closed room with one burning cigarette inside. After treatment with the reagent contained in the auto span diagnostic kit, the hypolipidemic activity was assessed by detecting the amount of blood serum in UV at 505 nm. A dosage of Methanolic and aqueous extracts of QI was generated using distilled water, i.e. 100 mg/kg p.o. At varying concentrations and dosages, both QI extracts significantly reduce the hazardous lipid layer in blood serum. This indicates that the plant possesses hypolipidemic properties. It significantly reduces LDL, VLDL, cholesterol, triglycerides, and elevates HDL levels in blood serum, which might be due to the plants' antioxidants suppressing lipid peroxidation. Our findings suggest that methanolic plant extracts are superior than aqueous extracts in terms of reducing harmful lipids and restoring lipid metabolism abnormalities in hyperlipidemic patients.

Author(s) Details:

Jyoti Sahu,
Bharat Institute of Technology, Ibrahimpatnam and Siddhi Vinayak Institute of Technology, Bilaspur, Chhattisgarh, India.

Pushpendra Kumar Patel,
Bharat Institute of Technology, Ibrahimpatnam and Siddhi Vinayak Institute of Technology, Bilaspur, Chhattisgarh, India.

Please see the link here: https://stm.bookpi.org/CAPRV-3/article/view/6941