A Review of Literature on Mrkh Syndrome | Chapter 12 | New Frontiers in Medicine and Medical Research Vol. 1

 In the absence of normal secondary sexual characteristics, primary amenorrhea is defined as the inability to attain menarche until the age of 14, or until the age of 16 in the absence of secondary sexual features. The most prevalent cause of primary amenorrhea is gonadal disease, followed by MRKH syndrome. MRKH syndrome is a rare congenital disorder characterised by uterine and vaginal wall aplasia. When the Müllerian duct fails to mature properly, this occurs. Once every 4500 female births, this happens. The majority of women suffer from primary amenorrhea. It's identified by the presence of normal secondary sexual characteristics, a normal 46 XX genotype, and a normal 46 XX genotype. The majority of instances have normal ovarian function, as well as a missing or underdeveloped uterus and upper section (2/3) of vagina. Type A is an isolated illness, but type B is associated with a variety of renal, skeletal, and cardiac problems. Treatment methods include psychological counselling and vaginoplasty. Vaginoplasty can be done in a variety of ways, both non-surgical and surgical. The authors conduct a literature review on the embryology, etiopathogenesis, work-up, and treatment of MRKH syndrome.

Author (s) Details

Nidhi Jain
Department of Obstetrics and Gynecology, Maharaja Agarsein Medical College, Agroha, Hisar, Haryana, India.

Jyotsna Harlalka Kamra
Department of Obstetrics and Gynecology, Maharaja Agarsein Medical College, Agroha, Hisar, Haryana, India.

View Book :- https://stm.bookpi.org/NFMMR-V1/article/view/2791