Anabolic androgenic steroids (AAS) are synthetic versions of testosterone, the male sex hormone. In this study, we looked at the effects of one of the AAS chemicals, 17-methyltestosterone, on acethylcholinesterase (AChE) enzyme activity in the forebrain, hippocampus, midbrain, and hindbrain of mice.
Adult female mice were randomly assigned to one of four experimental groups, each of which received different dosages of 17-Methyltestosterone (17-MT-0.5, 5.0, and 7.5 mg/kg bwt, respectively) s.c. for 30 days.Results: A considerable increase in AChE activity in the forebrain and midbrain (low and medium dose treatment) shows that cholinergic neurotransmission efficiency is reduced due to a drop in acetylcholine levels in the trans-synaptic cleft. Furthermore, in 17-MT treated mice, a concomitant drop in AChE activity was detected in the entire brain, hippocampus, and hindbrain, implying that neuronal transmission is impaired. Because AChE activity is mostly responsible for the control of the cholinergic system through acetylcholine hydrolysis, a major decrease in its activity in mice may result in stress-related anxiety, memory loss, and various cognitive and behavioural changes.
Conclusion: Based on the findings, we hypothesise that 17-MT, an alkylated steroid molecule, has a deleterious impact on AChE enzyme activity in several areas of the mouse brain, resulting in neuronal transmission impairment.
Author (S) Details
Sachin B. Patil
Molecular Endocrinology, Reproduction and Development Laboratory, Department of Zoology, Karnatak University, Dharwad-580 003, India.
Praveenkumar Kondaguli
Molecular Endocrinology, Reproduction and Development Laboratory, Department of Zoology, Karnatak University, Dharwad-580 003, India.
Laxmi S. Inamdar
Molecular Endocrinology, Reproduction and Development Laboratory, Department of Zoology, Karnatak University, Dharwad-580 003, India.
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