Background: Because the liver is the primary organ for xenobiotic biotransformation, hepatic diseases or degeneration are still a serious health concern today. Even if there are several antioxidants and hepatoprotectives available, liver deterioration that has progressed beyond the ability to heal culminates in liver failure and death.
The goal of this study was to see if an aqueous and alcoholic extract of Acorus
calamus rhizomes might protect rats against paracetamol-induced hepatotoxicity.
Hepatotoxicity was caused by taking paracetamol orally, and chemical parameters
such glutathione peroxidase, glutathione reductase, glutathione, Catalase,
lipid peroxidation, and histological alterations in the liver were compared to
Silymarin, a typical hepatoprotective medication.
After paracetamol administration, treatment of rats with aqueous and alcoholic
extracts of Acoruscalamus rhizome normalised the changed levels of the
aforesaid parameters, which may be equivalent to Silymarin and Vit-E.
Histopathological analysis of the liver tissue of control and treated animals
verified the hepatoprotective action.
Conclusion: Based on the findings, it may be inferred that the rhizome of
Acorus calamus protects rats against paracetamol-induced hepatotoxicity. The
usage of Acoruscalamus may be indicated for lifestyle-related disorders such as
hepatitis, as well as to promote overall health in animals, including humans.
Prior to the therapeutic use of Acoruscalamus as an antioxidant, extensive
investigations in target species should be conducted.
Author(s) Details:
G. Srividya,
Department of Veterinary Pharmacology and Toxicology, N. T. R College of
Veterinary Science, Gannavaram, India.
K. Adilaxmamma,
Department of Veterinary Pharmacology and Toxicology, College of Veterinary
Science Tirupati, Andhrapradesh, India.
C. H. Srilatha,
Department of Veterinary Pathology, College of Veterinary Science Tirupati,
Andhrapradesh, India.
