Floating tablets are a new gastro-retentive drug delivery technology that floats in the stomach and provides a controlled effect. Mentha Piperita is a natural herbal remedy that has carminative, anti-oxidant, and ulcer-inhibiting qualities, as well as boosting mucosal resistance to toxic chemicals. An purpose of the current study is to develop floating tablets of Mentha Piperita herbal extract as a medicament for the successful treatment of stomach ulcers based on the concepts. Methods: Direct compression floating tablets containing HPMC K100M and Hibiscus Rosa-sinensis mucilage in various formulations were made and the relevant parameters were analysed. The resultant powder blend was exposed to micromeritic properties, which showed good flow characteristics, depending on the varied ratios. The post-compression properties of prepared tablets were studied, and no significant difference was found. The percentage drug content yielded substantial results (90.990.15 to 98.530.32%), indicating that drug distribution is widespread. over a swath of floating tablets with medication F1 formulation had the highest swelling index (78.12 percent) up to 8 hours. F1 has the maximum floating efficiency (>13 hours), the shortest floating lag time (0.330.1sec), and good buoyancy qualities, according to in-vitro buoyancy experiments. F1 demonstrates more controlled release (70.610.11%) up to 72 hours, according to an in-vitro drug release investigation. In-vitro kinetic models were also confirmed to have zero order kinetics, and medicament release follows a Non-Fickian diffusion mechanism. Conclusions: The newly developed gastro-retentive floating tablets based on Mentha piperita extract are more effective for stomach-specific medication administration, particularly in ulcer disease, and are appropriate for potential therapeutic purposes while also improving patient compliance.
Author(s) Details
Dr. Nethaji Ramalingam
Department of Pharmaceutics, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram-673634, Kerala, India.
Aiswarya Madathil
Department of Pharmaceutics, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram-673634, Kerala, India.
Neethu Krishna
Department of Pharmaceutics, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram-673634, Kerala, India.
S. Sudha
Department of Pharmaceutics, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram-673634, Kerala, India.
K. R. Vimal
Department of Pharmaceutics, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram-673634, Kerala, India.
Babu Ganesan
Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram-673634, Kerala, India.
N. Dakshan Kumar
Department of Food Science and Technology, IK Gujral Punjab Technical University, Kapurthala-144603, Punjab, India.
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