The goal of this study was to see if -keto
analogues of essential amino acids (KAA) as a supplement could help those with
chronic renal disease (CKD). Methods: A prospective comparative study in
patients with CKD was conducted in a tertiary care hospital in North India. The
patients were divided into two interventional groups. Patients in Group I
(control) received conservative management and placebo, while patients in Group
II (KAA) received conservative management and KAA (600 mg, thrice daily) for 12
weeks. At 0, 4, 8, and 12 weeks of medication, hemograms, renal function tests,
lipid profiles, and side events were all reported. Results: Both groups
improved gradually in clinical characteristics after 12 weeks of treatment,
albeit the KAA group improved more pronouncedly than the control group. In
comparison to their pre-treatment levels, both groups showed a sustained
improvement in biochemical markers, with the KAA supplemented group exhibiting
a higher improvement. The levels of creatinine and total urine protein were
both lower after 24 hours. The glomerular filtration rate, haemoglobin, and
total urine volume in 24 hours all rose. The KAA group showed a significant
(p0.05) improvement in lipid profiles when compared to the control group. There
was no significant difference between the two groups in terms of side effects
(p>0.05). Conclusion: KAA supplementation in combination with conservative
therapy is beneficial and safe in delaying disease progression in patients with
CKD.
Author(s) Details
Dr. Irfan Ahmad Khan
Department of Pharmacology, J.N. Medical College Hospital, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India.
View Book :- https://stm.bookpi.org/TIPR-V9/article/view/2520
No comments:
Post a Comment