Different parts of Piliostigma
thonningii Scum (Caesalpinioideae) have been used medicinally. The
roots and twigs have been used locally in the treatment
of dysentery, fever, respiratory ailments,
snake bites, hookworm and skin infections in Eastern
Nigeria. The leaf extracts have been used for
various ethnomedicinal purposes including the treatment
of malaria all over Eastern Nigeria. In this
study, we have investigated the inhibitory effects of
the crude ethanol and methanol extracts for in
vitro antimalarial activity against
chloroquine resistant Plasmodium falciparum clone
(W2-Indo-China
isolates). The aqueous screening using reported
methodologies for phytochemical screening and in
vitro test methods, revealed the presence
of alkaloids, tannins, saponins, steroid, terpenoids,
flavonoids, cardiac glycosides and anthraquinones. The
crude leaf extracts obtained were tested for in vitro antimalarial
activity using chloroquine resistant strain of P. falciparum
clone (W2 – Indochina
isolates). The 50% inhibitory concentrations (IC50) were
evaluated after 48-72 h contacts between the
extracts and the parasite culture. The 50% inhibitory
concentration values for both the crude amide
ethanolic extract and the partially purified methanolic
extract ranged between 6.20 - 15.06 µg/ml.
While that of chloroquine was 0.316 µg/ml. This study
suggested that P. thonningii leaf extract
possess a significant level of antimalarial activity.
Author
(s) Details
Dr. Andrew Kwaji
Chemistry Department, Faculty of Sciences, University of Maiduguri, P.M.B
1069, Borno State, Nigeria.
Dr. P. U. Bassi
Clinical Pharmacology Unit, Department of Medicine, University of Maiduguri
Teaching Hospital, Borno State, Nigeria.
M. Aoill
Chemistry Department, Faculty of Sciences, University of Maiduguri,
P.M.B 1069, Borno State, Nigeria.
C. M. Nneji
Institute for Medical Research and Training, College of Medicine,
UCH, Ibadan, Oyo State, Nigeria.
Professor G. Ademowo
Institute for Medical Research and Training, College of Medicine, UCH,
Ibadan, Oyo State, Nigeria.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/270
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