This study aimed to report the case of a female patient with
chronic myeloid leukemia affected by
cryptococcal meningitis. ML, white, 48 years old, female sex, previously
diagnosed with chronic
myeloid leukemia that has been refractive to the use of imatinib and who has
recently begun using
nilotinib, was admitted complaining of sudden and disabling migraine in the
last 1 month associated
with asthenia, adinamia, anorexia, disinterest for daily activities, dizziness,
nausea, and vomiting. She
evolved with ataxia, and started to stroll with help and showed decrease of
muscular strength in her
upper limbs. The cerebrospinal fluid showed presence of Cryptococcus sp. and, therefore, we began
treatment with intravenous liposomalamphotericin B in the dose of 3 mg/kg/day,
for 6 weeks. A new
cerebrospinal fluid analysis, at the end of treatment, also showed rare
structures that are compatible
with Cryptococcus sp. After stabilization and
clinical improvement, she was discharged. After 3
weeks, she was hospitalized again with degeneration of the condition, and died
due to intracranial
hypertension secondary to cryptococcal infection. This report reinforces the
need of reflecting on fungi
pathologies, especially in immunosuppressant patients, as well as the
importance of early diagnosing
and making a fast intervention, with the aims of providing quality of life and comfort
to the patient and
of minimizing neurological sequelae to the patient.
Author (s) Details
Ricardo Parente Garcia Vieira
School of Medicine, Universidade Federal do Cariri, Barbalha, Brazil.
Jucier Gonçalves Júnior
Medical Residency Program in Internal Medicine, Santa Casa de Misericórdia de
Fortaleza, Fortaleza, Brazil.
Acácio Vieira Machado Leite
School of Medicine, Universidade Federal do Cariri, Barbalha, Brazil.
Viviane Chaves Pereira
School of Medicine, Universidade Federal do Cariri, Barbalha, Brazil.
Nélio Barreto Vieira
School of Medicine, Universidade Federal do Cariri, Barbalha, Brazil.
Modesto Leite Rolim-Neto
School of Medicine, Universidade Federal do Cariri, Barbalha, Brazil.
View Book:- https://bp.bookpi.org/index.php/bpi/catalog/book/270
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