Recalcitrant warts can accurately be defined as warts that persist after six months of conventional therapy. Traditional treatment options for warts include topical salicylic acid, cryotherapy, and electrocautery; however, patients with recalcitrant warts remain a major therapeutic challenge. There is evidence that immunotherapy can clear recalcitrant warts if traditional treatment fails. Given this, clinical studies published in PubMed and Google Scholar that used Bacillus Calmette-Guerin (BCG), Mycobacterium Indicus Pranii (Mw vaccine), and purified protein derivative (PPD) as immunotherapy for wart, were reviewed in this study. Neither of these treatments has been subjected to a randomized controlled trial, thus to date, there are no standardized protocols to use them. Our review highlights the scientific facts in the clinical applications of the previous options to treat recalcitrant warts and investigate the differences among them, concerning efficacy, adverse effects, dosage, and route of administration.Mw vaccine consists of heat-killed bacilli in a buffer solution, and its use neither needs a prior tuberculin test nor has a specific age group. Further randomized controlled studies are required to obtain more information to construct a therapeutic protocol.
Author
(s) Details
Nabeel K. Al Hamzawi,
Department
of Dermatology, Diwaniyah Teaching Hospital, Diwaniyah, Iraq
Mais H. Abdallah
Department of Dermatology, Diwaniyah Teaching Hospital, Diwaniyah, Iraq.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/264
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