Arsenic is a proven but enigmatic carcinogen. It produces human cancer although the mechanism is unclear. It doesn’t induces point mutation. Therefore the general procedure of cancer promotion is missing here and epigenetic events has been mooted as an alternate pathway of arsenic induced carcinogenesis. Aberrant DNA methylation and histone modification has been classified and proven as the mechanism of arsenic induced carcinogenesis. Arsenic methylation and DNA methylation both the pathways are using same enzymes and methyl donor. Therefore, the role of arsenic metabolising gene and there polymorphisms in DNA methylation has been analysed and a positive association has been found. We have also analysed the degree of histone modifications and it’s role in arsenic induced cancer. Gene expression and association of mi RNA has been pointed out to explore the molecular mechanism of arsenic induced cancer. Although the scope is limited, this paper also lighten on the future therapeutics of arsenic induced cancer. This is a platform on which many of our future research can be based on, although it lack the power of discussion about nutritional aspects and it’s association with aberrant methylation and subsequent development of cancer.
Author (s) Details
Dr. Sarmishtha Chanda
Department of Physiology, West Bengal Education Service, West Bengal, India.
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