Piperine is a naturally occurring alkaloid which can be
considered as major bioactive phytochemical
having broad spectrum of pharmacological activities. It
is obtained from the most valuable
ethnomedicinal spices peppercorns i.e. black pepper
and white pepper, which are the fruits of the
Asian vine Piper nigrum L. The
present article reveals a simple and effective isolation method of bulk
piperine. The novelty of this investigation is to
provide an idea for utilizing such natural method of
large scale commercial piperine production as API drug
in spite of chemical synthesis. Piperine was
isolated in a pure crystal form and characterized by
its melting point, X-Ray diffraction (XRD) studies
and spectral data, including two-dimensional nuclear
magnetic resonance (2D-NMR) spectroscopy.
Chromatographic techniques like Thin Layer
Chromatography (TLC) and High Performance Liquid
Chromatography (HPLC) were applied to determine the
purity of the yielded piperine. Considering the
yield results of value and purity it is indicated that,
such effective isolation method can be successfully
utilized for industrial large-scale production
commercially. According to the result, it can be claimed
that, as a natural product the isolated piperine can
also be utilized as API drug like other expensive
chemically synthesized piperine in different drug
formulation.
Author
(s) Details
Mrs. Zihan Rahman Khan
Pharmaceutical Sciences Research Division, BCSIR Laboratories, Dhaka,
Bangladesh Council of Scientific and Industrial Research (BCSIR), Bangladesh.
Dr. Md. Hossain Sohrab
Pharmaceutical Sciences Research Division, BCSIR Laboratories, Dhaka,
Bangladesh Council of Scientific and Industrial Research (BCSIR), Bangladesh.
Fatema Moni
Pharmaceutical Sciences Research Division, BCSIR Laboratories, Dhaka,
Bangladesh Council of Scientific and Industrial Research (BCSIR), Bangladesh.
Suriya Sharmin
Pharmaceutical Sciences Research Division, BCSIR Laboratories, Dhaka,
Bangladesh Council of Scientific and Industrial Research (BCSIR), Bangladesh.
Dr. Farhana Afroz
Pharmaceutical Sciences Research Division, BCSIR Laboratories, Dhaka,
Bangladesh Council of Scientific and Industrial Research (BCSIR), Bangladesh.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/269
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