This is a feasibility study on improving the spatial
resolution of clinical PET, by slightly renovating the
PET scanner design such that high spatial resolution
working modes (HSRWM) are achievable.
Introduction:
The poor spatial resolution of prevalent PET imaging has restrained its
sensitivity in
imaging small lesions, e.g. early-stage cancers or
small metastasis. This drawback is caused by 2
essential requirements in clinic: A relatively large
diameter (e.g. 80cm) for PET scanner to accumulate
patients, and sizeable scintillator detectors to
maintain a reasonable collecting efficiency. In recent
decade more efforts focused on improvement of detector
resolution, e.g. digital PET, since the
request on ring diameter is fundamental.
Methods:
The novel concept of equivalent position of imaging was proposed
for the first time. A
typical static PET scan can be virtually considered as
superposition of m equivalent sub-scans at m
different equivalent imaging positions, when the scanner ring is
systematically adjusted its angular
orientation within one detector size. In this case each
detector is virtually divided into m equal
subdetectors, without physical minimizing the detector size. The contributions
of those sub-scans are
analytical by an m x m matrix. The
time for performing a high-resolution scan could be comparable to
a typical PET scan, as long as the Poisson noises are
insignificant to low-uptake voxels.
Discussion:
Three dimensional modeling for imaging at different m were also
conducted. As a result,
for a typical scanner design e.g. 80cm in diameter with
18F as tracers, the spatial resolution of
double
sub-scans (m =2) is
2.56mm, and 2.19mm for triple sub-scans (m=3). Scanning
at high m (m>2) will
slightly drop contrast resolution, hence m=2 is
preferably recommended.
Conclusion:
As a compatible approach to digital PET and other technological
renovation, the novel
HSRWM design is feasible, enabling PET to image small
lesions in clinic.
Author
(s) Details
Kelin Wang
Assistant Professor Department of Radiation Oncology, Penn State Health
Milton S. Hershey Medical Center Hershey, PA 17033-0850, USA.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/270
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