This study was conducted to
investigate the validity of serum sorbitol and Vascular Endothelial
Growth Factor A (VEGF-A) in diagnosing DR and
differentiating it from diabetes without retinopathy
(DNR). A cross-sectional study included 164 diabetes
mellitus patients: 30 patients with no
retinopathy (the control group), 86 patients with
non-proliferative diabetic retinopathy (NPDR), and 48
patients with Proliferative Diabetic Retinopathy (PDR).
Patients were referred to the Layla Qasim
Diabetic Center between November 2016 and October 2017
and an ophthalmologist established a DR diagnosis
using OCT. Serum sorbitol and serum VEGF-A were measured for all patients. By
using
study biomarkers, the cut-off values of VEGF-A (124.7
ng/ml) and sorbitol (0.3112 mg/ml) were
established, and their validity parameters. For VEGF-A,
the specificity was 73.1 the sensitivity was 80
and 76.2% of the observed agreement. The combined
parallel test was applied as negative if both the
tests were negative or as positive if either of the
tests was positive: a highly significant statistical
agreement (Kappa test p<0.001)
was found with the gold standard diagnosis (OCT), with 85.4% of
observed agreement. A combination of serum sorbitol and
VEGF-A for diagnosing DR and for
differentiating DR from DNR patients exhibits a
significant agreement with an OCT diagnosis.
Author
(s) Details
Dr. Sanaa Gadbaan Hama
Almandlawi
Department of Clinical Analysis, Hawler Medical University, College of
Pharmacy, Ministry of Higher Education, Kurdistan Region Government, Erbil,
Iraq.
Muhanad Salah Mawlood
Department
of Clinical Analysis, Hawler Medical University, College of Pharmacy, Ministry
of Higher Education, Kurdistan Region Government, Erbil, Iraq.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/270
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