Malignancy at the molecular and cellular
microenvironment levels can be defined as a state established in the setting of
particular tumour-host relationships. R.E, R.E. The definition of
"tumour-host" interaction was clearly illustrated by Kavetsky and his
collaborators. A tumour is a complex biological system that is closely linked
to Linked to the body, where it is
initiated and created. In the environment, tumour cells are various factors
that form a tumour microenvironment that plays an important role in the
progression of the disease. Two forms of tumour microenvironment are available:
the metabolic microenvironment mediated by variables Microphysiology of the tumour (blood flow,
vascular permeability, oxygenation, extracellular pressure, interstitial fluid
pressure, etc.) and cellular-molecular microenvironment, including interactions
between tumour and non-tumor cells and stromal compartment influences. Tumour
Causes The interaction between tumour cells and surrounding non-tumor cells and
molecular components can be changed by microphysiology, and they also form the
tumour profile that influences the host tumour pressure. The analysis presents
data on the function of the metabolic microenvironment of tumour cells from the
tumour-host interaction point in order to use these parameters to assess the
diagnostic and prognostic methods for the outcome of disease in patients with
gastric cancer. Hypoxia has been given special attention as a key factor in the
metabolic microenvironment, which is optimistic. It influences the development of the tumour,
promotes its aggressiveness, metastasis and resistance to therapy, and is
considered an unfavourable prognostic factor. The clinical significance of
tumour classification based on the degree of tumour oxygenation has been shown
to be possible, which can be helpful for selecting patients for individualised
treatment that can offer hope for improvement.
With clinical effectiveness.
Author (s) Details
Dr. L. Bubnovskaya
R. E. Kavetsky Institute of Experimental Pathology, Oncology and
Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Dr. D. Osinsky
City Clinical Oncological Center, Kyiv, Ukraine.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/272
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