The resistance (T,
the time before apnoea) to extreme hypobaric hypoxia (SHBH) is prolonged by a
single mild hypobaric hypoxia (HBH). There is strong therapeutic potential for
this hypoxic preconditioning effect. In our analysis with medium, moderate and
high SHBH on intact rats and those pre-tested under SHBH We found resistance to it, that the hypoxic
preconditioning removed the discrepancies between groups of rats with different
innate resistance to it and with different previous hypoxic experiences in
resistance to extreme hypoxia. To assume that the hypoxic preconditioning is
realised on its own was rational. Mechanisms.
Mechanisms. Methods for predicting the efficacy of pre-conditioning action were
required to investigate these processes, but these methods were not available.
In the quest process, we discovered in the intact rats a clear correlation in
the acoustic startle reaction model, which we called the PPI-T test, between
the efficiency of HBH and prepulse inhibition (PPI). In neurobiology and
psychiatry, this model is commonly used; PPI, however, has not previously been
used as a predictor of hypoxic preconditioning. We have, therefore, shown its
validity. In order to predict the efficiency of the preconditioning action on
intact animals and to research its mechanisms, the PPI-T test can be used.
Author (s) Details
Elena I. Zakharova
Laboratory of General Pathology of Cardiorespiratory System, Institute of
General Pathology and Pathophysiology, Baltic Street 8, 125315 Moscow, Russia.
Zinaida I. Storozheva
Laboratory of Clinical Neurophysiology, Serbsky’
National Medical Research Center for Psychiatry and Narcology, Kropotkinsky
per., 23, 111395 Moscow, Russia.
Andrey T. Proshin
Laboratory of Functional Neurochemistry, P.K. Anokhin’ Institute of
Normal Physiology, Baltic Street 8, 125315 Moscow, Russia.
Mikhail Yu. Monakov
Laboratory of General Pathology of Cardiorespiratory System,
Institute of General Pathology and Pathophysiology, Baltic Street 8, 125315
Moscow, Russia.
Alexander M. Dudchenko
Laboratory of General Pathology of Cardiorespiratory System, Institute of
General Pathology and Pathophysiology, Baltic Street 8, 125315 Moscow, Russia.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/272
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