Treatment with collagenase clostridium histolyticum has been
shown to be effective at the short- and
mid-term against Dupuytren’s contracture in which cords
have formed. As with any new drug,
pharmacovigilance studies will allow for reporting new
complications with the treatment.
We present a clinical case of vasospasm after
collagenase clostridium histolyticum infiltration in a
patient with a 60º affectation of the proximal
interphalangeal joint forming an ulnar cord of fifth radius
in the left hand. Evolution at one year presents the
cord in the same contracture as before, and no
vascular alteration. In
our opinion, most complications from infiltration with collagenase clostridium
histolyticum take place when the treatment is
performed and are due to extravasation of the infiltration into healthy
tissue.In cases of greater extravasation,
vessels may be affected causing transient vasospasms due to the local action of the enzyme, together with a secondary
inflammatory reaction to the collagenase action.
Author
(s) Detaiis
R. Sanjuan-Cerveró
Department of Orthopaedic Surgery and Traumatology, Upper Limb Unit,
Hospital Denia, Denia, Spain.
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