To evaluate the effects of the aqueous extract of Baillonella
toxisperma stem bark on dexamethasone
induced insulin resistance in rats, a quantitative
phytochemical study has done extract for the
quantification of bioactive compound such as: total
phenol, flavonoid, and flavonol. The induction of
insulin resistance has been done by intraperitoneal
injection of dexamethasone (1 mg/kg) for 8 day;
metformin (40 mg/kg) and aqueous extract (60, 120 and
240 mg/kg) were administrated orally, one
hour before intraperitoneal injection of dexamethasone.
During this experiment, body weight and
blood glucose level were evaluated the first and the
last day (days 1 and 8) and a glucose tolerant
test was performed in rats the last day. Thereafter,
animals were sacrificed and blood samples were
collected for the determination of lipids parameters,
transaminases (ALT and AST) and total protein
level. Organs such as: liver, pancreas, and kidneys
were also collected for the relative organ weight
determination. At the end of this study, the results
showed that the aqueous extract of B. toxisperma
contain a high quantity of phenols, flavonoids, and
flavonols, significantly reversed the metabolic
alterations (lipid profile, protein level, and
transaminase activity) induced by dexamethasone in rats.
This extract significantly decreased (p < 0.05; p
< 0.01) postprandial hyperglycemia in insulin
resistance rats at dose of 60 and 120 mg/kg. The
results suggest that Baillonella toxisperma would
be
able to correct the metabolic alteration induced by
insulin resistance and thus, may be useful for the
treatment of type 2 diabetes mellitus.
Author
(s) Details
Sylvie
Léa Wansi Ngnokam
Department of Animal Biology, Faculty of Science,
University of Dschang, P. O. Box 67, Dschang, Cameroon.
Marius Trésor Wego
Department of Animal Biology, Faculty of Science, University of Dschang, P.
O. Box 67, Dschang, Cameroon.
Sylviane Laure Poualeu Kamani
Department of Animal Biology, Faculty of Science, University of Dschang,
P.O.Box 67, Dschang, Cameroon.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/267
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