Two simple, sensitive, accurate, precise, rapid and
economical methods were developed for the
simultaneous estimation of Ofloxacin and Ornidazole
from combined tablet dosage form. First method
is based simultaneous equations and second method is
based on Q-analysis (absorbance ratio
method). Ofloxacin and Ornidazole show absorbance
maxima at 293nm and 275nm in 0.1N HCI
respectively. The linearity was obtained in the
concentration ranges of 2-14 μg/ml for Ofloxacin and 5-
35 μg/ml for Ornidazole with Regression Coefficient (R2) greater
than 0.999. In the first method
concentration and subsequently amount of drug
determined by using simultaneous equations and in
second method concentration and amount of drugs
determined by using ratio of absorbance at isoabsorptive point(which was found
to be 284 nm) and at λmax of one of the drug. The results of
analysis have been validated statistically and by assay
and recovery studies. Therefore the proposed
validated method can be successfully applied for
routine quality control analysis and simultaneous
determination of Ofloxacin and Ornidazole in combined
drug formulations.
Author
(s) Details
Dr. Pralhad Rege
Department of Chemistry, St. Xavier’s College, Maharashtra, India.
Mr. Kyle Meyers
Department of Chemistry, St. Xavier’s College, Maharashtra, India.
Ms. Neha Kapadia
Department of Chemistry, St. Xavier’s College, Maharashtra, India.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/269
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