Pain sensation is characterized as a complex experience,
dependent on sensory processes but also
on the activation of emotional operations in limbic
brain areas. A network analysis suggested that
there are broad-ranging, as well as specific changes
with a focus on prefrontal regions, the anterior
insula, thalamus, anterior cingulate cortex, central
amygdala, periaqueductal grey matter, and other
midbrain structures. This chapter provides an original
account of behavioral aspects with important
ramifications for the study of brain mechanisms of
analgesia by widely used non-steroidal antiinflammatory drugs in rodent’s
formalin test. It explains, in terms of specified somato-sensory
machinery and systems, mechanisms of antinociception by
these non-opioid drugs in pain matrix key
structures of brain limbic areas, – the anterior cingulated
cortex, agranular insular cortex, and central
amygdala, – with testing thermal and mechanical
withdrawal reflexes in rats. In these experimental
paradigms, the chapter presents a study the roles of
endogenous opioid and cannabinoid systems in
brain descending pain control mechanisms.
Author
(s) Details
Natia Tsagareli
Laboratory of Pain and Analgesia, Beritashvili Center for Experimental
Biomedicine, 0160 Tbilisi, Georgia and Department of Physiology, Tbilisi State
Medical University, 0177 Tbilisi, Georgia.
Nana Tsiklauri
Laboratory of Pain and Analgesia, Beritashvili Center for Experimental
Biomedicine, 0160 Tbilisi, Georgia.
Irina Kvachadze
Department of Physiology, Tbilisi State Medical University, 0177 Tbilisi,
Georgia.
Merab G. Tsagareli
Laboratory of Pain and Analgesia, Beritashvili Center for Experimental
Biomedicine, 0160 Tbilisi, Georgia and Department of Physiology, Tbilisi State
Medical University, 0177 Tbilisi, Georgia.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/269
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