This work reviews on the optimization
and evaluation of pluronic polymers based thermo-responsive
in-situ hydrogels which is used specifically for
ophthalmic purposes. The method of preparation using
cold method and different physicochemical properties
that affect hydrogel preparations include pH,
flow ability, transition of sol–gel, temperature,
gelling capacity and rheological properties were briefly
reviewed. Based on in-vitro release
studies and gelling capacity, how the best formulation could be
selected and analyzed has been widely discussed in this
work. Literature reports on the study of
different autoclaving (both before and after) and
irritation studies in rabbits were reviewed. In addition,
the aqueous humour analysis done using albino rabbits
was also reported. Through this review, it was
inferred that the increase in pluronic polymer
concentration increase the physiochemical property of
sol–gel transition temperature. Further, these types of
hydrogels are widely established as secured
especially for usage ophthalmic products and it might
significantly improve drug bioavailability in
humour analysis. It is concluded that the optimized
in-situ hydrogels could be a promising substitute to conventional eye drops.
Author
(s) Details
B. Anbarasan
Department
of Pharmaceutics, Faculty of Pharmacy, Sri Ramachandra Institute of Higher
Education and Research (DU), Porur, Chennai-600116, India.
J. Thanka
Department
of Pathology, Sri Ramachandra Institute of Higher Education and Research (DU),
Porur, Chennai-600116, India.
S. Ramaprabhu
Department
of Physics, Alternative Energy and Nanotechnology Laboratory (AENL), Nano
Functional Materials Technology Centre (NFMTC), Indian Institute of Technology,
Chennai-600036, India.
S. Shanmuganathan
Department of Pharmaceutics, Faculty of Pharmacy, Sri Ramachandra
Institute of Higher Education and Research (DU), Porur, Chennai-600116, India.
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