Oxygen and oxidative stress are key factors for all the
living matter on our planet. It is obvious that all
the cells of these organisms must be provided of
adequate protections either for the control of the
oxygen concentrations or for the excess of the
oxidative stress. Thus, it is not surprising that the
Nobel Prize in Physiology or Medicine 2019 was awarded
jointly to William G. Kaelin Jr, Sir Peter J.
Ratcliffe and Gregg L. Semenza "for their
discoveries of how cells sense and adapt to oxygen
availability". No less important is the role
of an excess of oxidative stress which could derive from an
imbalance between the production of energy in the
mitochondria, with a consequent increase in free
radicals, and the antioxidant capability of our cells.
In recent scientific literatures, it is emerging the
possibility that ozone could upregulate the Nrf2
pathway related to the oxidative stress, thus indicating
a rational explanation of its surprising effects
induced at low doses in humans. Furthermore, it could
be of paramount importance for the control of the aging
process, reducing or ameliorating the
deleterious effects of oxidative stress.
Author
(s) Details
Lamberto Re,
Pharmacology Department at the University of Ancona, Italy and The
Scientific Advisory Board of WFOT (www.wfoot.org), Italy and Medinat Clinic,
Camerano (www.medinatsrl.com), Italy.
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/269
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