The current study was regard the formulation and artificial evaluation of buoyant microspheres of lamivudine by inclusion of various concentrations of HPMC K 100M, to increase the stomachic residence period of lamivudine and reduced portion of drug or other consumable frequency. Floating drug transfer system is individual of the methods to increase the stomachic residence period. Preformulation studies acted to confirm the innocence of drug and to find the drug excipient interactions accompanying FTIR studies. The ionotropic gelation process was used to create the gastro strong floating microspheres. For SEM study, in-vitro buoyancy studies, and in-vitro disintegrating studies, the produced microspheres were determined. By utilizing FTIR and DSC analysis, the unity of the medicine and excipient was confirmed. According to in-vitro drug release studies, formulation F5, that contains HPMC K100M as a release retardant polymer at a aggregation of 1:2 to the drug, was able to maintain drug release for up to 14 hours. The Korsmeyer equating and Higuchi's model were used to decide that the drug release mechanism from the buoyant microspheres was anomalous (non-Fickian) spread. Using HPMC K100M as a release retardant polymer, the gastro retentive buoyant microspheres of lamivudine were successfully devised and evaluated. Using the expression F5 with HPMC K100M at 1:2 concentrations to the drug, a slow and very large drug release unending up to 14 hours was noticed.
Author(s) Details:
Voleti Vijaya Kumar,
School of Pharmacy, Sathyabama Institute of
Science and Technology, Kamaraj Nagar, Semmancheri, Chennai, Tamil Nadu-600119,
India.
Kommu
Pradeep,
BA&KR
College of Pharmacy, NH-7, Ongole, Prakasam District, Andhra Pradesh, India.
R. Niranjan Kumar,
Santhiram College of Pharmacy, NH-18, Nandyal, Nandyal dist, Andhra
Pradesh-518501, India.
K. Ravikumar Kota,
Santhiram College of Pharmacy, NH-18, Nandyal, Nandyal dist, Andhra
Pradesh-518501, India.
Sadhu
Nelson Kumar,
Department of Pharmacology, P Ramireddy Memorial
College of Pharmacy, Kadapa, Andhra Pradesh, India.
C.
Rajaram,
Department
of Pharmacology, P Ramireddy Memorial College of Pharmacy, Kadapa, Andhra
Pradesh, India.
B. Narasimha Rao,
Department of Pharmaceutics, P Ramireddy Memorial College of Pharmacy,
Kadapa, Andhra Pradesh, India.
Y. Ismail,
Crescent School of Pharmacy, B.S. Abdur Rahaman Crescent Institute of
Science & Technology, Vandalur, Chennai, Tamil Nadu-600119, India.
P. Shanmuga Pandiyan,
School of Pharmacy, Sathyabama Institute of Science and Technology, Kamaraj
Nagar, Semmancheri, Chennai, Tamil Nadu-600119, India.
Please see the link here: https://stm.bookpi.org/COPS-V9/article/view/10171
No comments:
Post a Comment