The present study proposed to develop a novel RP-HPLC Method for the guess of Niacin and Lovastatin in Bulk and spoken solid dosage form. For the concurrent estimation of lovastatin and niacin in a linked dosage form, a simple, accurate, and fast HPLC method has existed created and validated. Chromatographic break-up of the two drugs was acted on a Purospher BDS C8 column (150 mm× 4.6 mm id, 5µm piece size). The travelling phase secondhand was a mixture of 0.1% v/v triethylamine (pH 5.0), holding 20 mM of Ammonium acetate buffer: methanol (30:70% v/v).Detection was acted at 237nm and sharp peaks were obtained for niacin and Lovastatin at memory times of 3.2±0.01 brief time period and.6.4±0.01 min individually. The calibration curve was uninterrupted in the concentration range 100-700µg/ml for niacin 3-18µg/ml for Lovastatin; the correlation coefficients were 0.9991 and 0.9992, individually. According to the International Conference on Harmonization (ICH) Q2 (R1) guidelines, the optimised procedure performed well in agreements of specificity, extent of object, detection and quantitation limits, accuracy, and accuracy. It has been proved that this assay can be used to frequently quantify lovastatin and niacin in medicine dosage form. High portion recovery of drug shows the arrangement is free from inference of excipients present in the expression. The proposed form was found appropriate for simultaneous reasoning of NI and LT can be secondhand for routine quality control of their most drug mixture and their combined portion of drug or other consumable form.
Author(s) Details:
G. S. Devika,
Department of Pharmaceutical Analysis, Cherraans
College of Pharmacy, Siruvani Main Road, Coimbatore, Tamil nadu, India.
R.
Ramesh Petchi,
Department
of Pharmacology, Cherraans College of Pharmacy, Siruvani Main Road, Coimbatore,
Tamil nadu, India.
M. Sudhakar,
Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy,
Maissamaguda, Dullapally, Secunderabad -14, Andrapradesh, India.
J. Venkateshwara Rao,
Department of Pharmaceutical Chemistry, Sultan Ul Uloom College of
Pharmacy, Road No 3, Banjara Hills, Secunderabad- 500034, Andra Pradesh, India.
Please see the link here: https://stm.bookpi.org/NAPR-V1/article/view/10429
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