Evaluation of Safety Profiles of a Herbal Wound Healing Formulation in Laboratory Animals | Chapter 11 | Novel Aspects on Pharmaceutical Research Vol. 1

 The present study stated an acute, Sub severe dermal safety and Mucus membrane sensitivity profile of AO and AO11 in lab animals. This is a very effective wound restorative oil expression developed in house. We have orderly studied the effect of the lubricate in Laboratory Animal for its hematological parameters and raise no hepato or renal toxicity associated with the substitute-chronic dermal exposure of investigational crop and investigational product11 in the animals. Wound is demarcated as the disruption of community tissues by violence or anguish. The restoration of injured or inflamed tissues back  to normal condition is judged as healing.Theformulations were arisen Curcuma longa Linn and Glycyrrhiza glabra Linn rhizomes, Hamiltonia suaveolens Roxb bark, Typha angustifolia Linn flowers, Azadirachta indica A.Juss leaveswithout/ with pig fat (AO and AO11 individually) mixed in sure proportion using Sesamum indicum Linn lubricate as a base, manufactured at a GMP ascertained facility. Acute, sub-severe dermal safety, gelled waste membrane irritation sketches were studied by OECD directions number 434, 410 and 405 in Wistar rats and New Zealand rabbits individually.This study was conducted using 10 men and 10 females Wistar rats engaging OECD guideline number 410. For acute study dermal request of 2000 mg/kg single measure and for sub-acute study limit lot protocol of 1000 mg/kg for 28 days was secondhand. For mucus membrane sensitivity test0.10ml dose was secondhand.In an acute study no local reaction, observable changes and mortality was noticed at 2000 mg/kg by dermal route till 14 days. In sub-acute study accompanying dermal application of 1000 mg/kg for 28 days, skilled were no abnormal signs/symptoms at the request site, sameness inbody weight, food devouring, hematology/enzyme sketches, urine analysis, relative tool weights and histopathological observations of internal organs in comparison to control animals. Mucus sheath of rabbits demonstrated no evidence of irritation for both formulations.

Author(s) Details:

S. B. Patankar,
ACE Hospital and Research Centre, 32/2a, Erandwana, Pune-411004, India.

A. M. Mujumdar,
ACE Hospital and Research Centre, 32/2a, Erandwana, Pune-411004, India.

T. Sane,
Department of Chemistry, Guru Nanak Institute of Research and Development, Matunga, Mumbai-400019, India.

U. Remya,
Department of Chemistry, Guru Nanak Institute of Research and Development, Matunga, Mumbai-400019, India.

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