Method Development and Validation for the Estimation of Bortezomib in Pure and Its Pharmaceutical Tablet Dosage form by UV Spectroscopy | Chapter 13 | Novel Aspects on Pharmaceutical Research Vol. 1

 Background: Bortezomib is an antagonistic-cancer cure used to treat multiple myeloma and mantle container lymphoma.Methods: The UV Spectroscopy method for reasoning of bortezomib was developed and legitimized as per ICH guidelines. The estimation of bortezomib in the clean and tablet portion of drug or other consumable form was carried out at the maximum absorbance at 365 nm.The Results: The order was found to be uninterrupted and obeys stout law in the aggregation range 5-25µg/ml with a correlation cooperative 0.999, the developed means was validated as per ICH directions and was found to be correct and precise.Conclusion: A accelerated novel precise and correct UV Spectroscopy method was grown and validated and can be secondhand for regular study for the estimation of bortezomib.

Author(s) Details:

R. Nageswara Rao,
Department of Pharmaceutical Analysis, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.

V. Ravikumar,
Department of Pharmaceutical Biotechnology, School of Pharmacy, Guru Nanak Institutions Technical Campus , Hyderabad, Telangana, India.

L. Shiva Shankar Reddy,
Department of Pharmaceutical Analysis, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.

D. Madhuri,
Department of Pharmaceutical Analysis, Creative Education Society’s College of Pharmacy, NH-7, Chinnetekur, Kurnool-518218, A. P. India.

N. Yellasubbaiah,
Department of Pharmaceutical Analysis, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.

S. V. Suresh Kumar,
Department of Pharmaceutical Analysis, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.

N. Madana Gopal,
Department of Pharmaceutical Analysis, Santhiram College of Pharmacy, Nandyal-518501, Andhra Pradesh, India.

S. Indradev,
Department of Pharmaceutical Analysis, Creative Education Society’s College of Pharmacy, NH-7, Chinnetekur, Kurnool-518218, A. P. India.

S. Vinay,
Department of Pharmaceutical Analysis, Creative Education Society’s College of Pharmacy, NH-7, Chinnetekur, Kurnool-518218, A. P. India.

S. Mahesh,
Department of Pharmaceutical Analysis, Creative Education Society’s College of Pharmacy, NH-7, Chinnetekur, Kurnool-518218, A. P. India.

P. Ajay Kumar,
Department of Pharmaceutical Analysis, Creative Education Society’s College of Pharmacy, NH-7, Chinnetekur, Kurnool-518218, A. P. India.

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