Notwithstanding
the endless efforts on targeted drug delivery, specially upon the arrisal of
uncontrallable moratlity rates due to SARS-COV-2 and cancer, there has never
been an FDA approved drug or a treatment approach. Therefore, this work was
dedicated to find a new approach to not only treat but also to image the
dynamics of SARS-COV-2. This work aimed at adding multiple aspects that
constitute a significant need to science and the worldwide health experts.
First, not only does it review the conventional treatment approaches such as
chemical, herbal, genetic, stem-cell
based or other therapies, but the review extends, for the first time, to
include all possible external triggers that could interact with SARS-COV-2.
Second, a generic treatment and imaging approach is then outlined, to expand
the range of benefit to all researchers who aim at continuity of study in this
field. Third, and importantly, the protocol is generic to be applicable to all
targeted drug delivery applications, which is detailed through the explanation
of the design objectives, requirements, and a guided, evidence-oriented
development of the selected protocol, which will be significant to other
targeted drug delivery applications such as cancer, with a manimial changes in
the dose, and coating. Fourth, exhaustive reviews have been conducted on the
chosen protocol involving electromagnetic interactions, which have not been
applied, due to the non-biodegradibility
of the gold or metal nanoparticles required to achieve a certain field
enhancement. In the meanwhile, more than 1300 materials that have been theoretically
or emperically studied to have a capability to target SARS-COV-2, have been
reviewed for their capability to achieve the required electromagnetic
interactions, but none of them could theoretically, at their best, provide the
required interaction specifications. Moreover, and fifth, an exhaustive review
for all field enhancement approaches have been reviewed in this work, as well,
but none of them could be applicable in this case of concern, for detailed
reasoning that has been provided in this work, too. Therefore, and sixth, a
novel field enhancement approach has been designed. This approach was intended
to help the entire world of drug delivery, since it is material independent,
which helps with the replicability of this approach to other targeted drug
delivery applications, even upon changing the targeting coating material.
Furthermore, the approach is verified numerically and empirically. Seventh, not
only does this work provide a novel field enhancement approach, but it sets up
an unprecedented, detailed roadmap for field enhancement to facilitate and
accelerate the entire world-wide research in this field. Eighth, this work
applies all of the outlined protocol milestones theoretically and practically
to verify it, which sets a pioneering gateway for the world of targeted drug
delivery, using novel perspectives. Ninth, this work was considering the
strictly limited technological capabilities
in Egypt, which is helpful in the sense of simplicity and
cost-efficiency, that suit other developing countries.
Author(s) Details:
A. Q. Noha,
Department
of Physics, Zewail City of Science and Technology, Giza, Egypt and Department
of Electronics and Communication Engineering, Faculty of Engineering, Ain Shams
University, Cairo, Egypt.
Please see the link here: https://stm.bookpi.org/AURTDDUPOGC/article/view/10225
No comments:
Post a Comment