Evaluating the Efficacy of Traditional Chinese Medicine (Marecipe AV) in the Treatment of Viral Infections in Animals: A Case Study on ASF, Avian Influenza, and Canine Diseases | Chapter 4 | Contemporary Research and Perspectives in Biological Science Vol. 5

Background: For more than a century, numerous medical researchers have attempted to discover remedies for viral illnesses. Unfortunately, except for vaccination, no safe and efficient cure has been discovered. There is still no effective treatment for acute viral infections. Marecipe AV therapeutics, a prescription compound of various herbs, has been utilized at our clinic for many years in the treatment of viral infectious diseases and has shown therapeutic effects. In order to obtain clear evidence of efficacy a series of experimental treatments with Marecipe AV has been conducted on animals with lethal viral infectious diseases.

Methods: The oral administration of Marecipe AV has been used to treat several naturally infected viral infections with high morbidity and mortality in animals. The efficacy was measured by comparing mortality rates between treated and untreated animals. An analysis of variance was performed on each data set. The Tukey-Kramer multiple comparisons test was utilized for comparisons of death between treatment groups. Statistics were performed with the Statistical Package for the Social Sciences (SPSS) version 24 for Windows.

Results: The mortality was 28.57% versus 100% among treated and untreated naturally infected pigs with ASF. The mortality was 0% versus 100% for treated and untreated cases when treatment was administered in the early presymptomatic stage.

The mortality was 39.04% versus 100% in treated and untreated naturally infected ducks with Avian influenza, and 0.86% versus 99.83% for treated and untreated ducks when treatment is given in the early presymptomatic stage. For chickens, the mortality was 4.60% versus 85% for treated and untreated, respectively. All surviving ducks and chickens ultimately achieved complete recovery.

For dogs with canine distemper and/or canine parvovirus, the mortality was 10.11% and 82.88% among the treated and untreated. For dogs infected with parvovirus only, the mortality was 0% for treated and 87.5% for untreated. Among dogs simultaneously infected with parvovirus and canine distemper, the mortality was 15.25% and 96.84% for treated and untreated, respectively. All surviving dogs fully recovered.

Conclusions: The findings indicate that Marecipe AV can save lives from several deadly viral infections and cure these viral infections. Marecipe AV therapeutics presents a new effective treatment Opportunity for acute viral infections. Further research is needed to fully understand its mechanisms and confirm its effectiveness through well-designed clinical trials.

 

Author (s) Details

Jiangnan Feng
Department of Medicine, Tongrun Tang Traditional Chinese Medicine Clinic, Nanchong City, Sichuan, China.

Zhenghua Ma
Department of Medicine, Tongrun Tang Traditional Chinese Medicine Clinic, Nanchong City, Sichuan, China.

 

Hua Wu
Department of Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

 

Chengsheng Yi
Department of Medicine, Tongrun Tang Traditional Chinese Medicine Clinic, Nanchong City, Sichuan, China.

 

Meiying Gao
Department of Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

 

Dengbin Zhu
Department of Medicine, Tongrun Tang Traditional Chinese Medicine Clinic, Nanchong City, Sichuan, China.

 

Minghai Ma
Department of Medicine, Tongrun Tang Traditional Chinese Medicine Clinic, Nanchong City, Sichuan, China.

 

Rui Cheng
Department of Medicine, Taipei Branch of Rui Peng Pet Hospital / Linjiang Branch of Kedao Animal Hospital, Wuhan, Hubei, China.

 

Xia Liua
Department of Medicine, Tongrun Tang Traditional Chinese Medicine Clinic, Nanchong City, Sichuan, China.

 

Xue Feng
Department of Medicine, Tongrun Tang Traditional Chinese Medicine Clinic, Nanchong City, Sichuan, China.

 

Xianfu Li
Department of Medicine, Zhongde Institute of Psychology, Wuhan, Hubei, China.

 

Yu Yan
Department of Medicine, Tongrun Tang Traditional Chinese Medicine Clinic, Nanchong City, Sichuan, China.

 

Please see the book here:- https://doi.org/10.9734/bpi/crpbs/v5/2814

Story of Sepsis| Book Publisher International

"Story of Sepsis" is a compelling journey through the history, pathophysiology, and organ dysfunction associated with sepsis. Tailored for young residents and enthusiastic physicians, this book sheds light on the latest updates and future prospects, empowering the medical community to combat this life-threatening condition.

 

Author (s) Details

Dr. K J Devendra Prasad
Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research (Deemed to be University) Tamaka, Kolar, Karnataka 563101, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-49238-75-6

An Unprecedented Revolution in Targeted Drug Delivery Using Photonics: Overcoming Global Challenges | Book Publisher International

Notwithstanding the endless efforts on targeted drug delivery, specially upon the arrisal of uncontrallable moratlity rates due to SARS-COV-2 and cancer, there has never been an FDA approved drug or a treatment approach. Therefore, this work was dedicated to find a new approach to not only treat but also to image the dynamics of SARS-COV-2. This work aimed at adding multiple aspects that constitute a significant need to science and the worldwide health experts. First, not only does it review the conventional treatment approaches such as chemical,  herbal, genetic, stem-cell based or other therapies, but the review extends, for the first time, to include all possible external triggers that could interact with SARS-COV-2. Second, a generic treatment and imaging approach is then outlined, to expand the range of benefit to all researchers who aim at continuity of study in this field. Third, and importantly, the protocol is generic to be applicable to all targeted drug delivery applications, which is detailed through the explanation of the design objectives, requirements, and a guided, evidence-oriented development of the selected protocol, which will be significant to other targeted drug delivery applications such as cancer, with a manimial changes in the dose, and coating. Fourth, exhaustive reviews have been conducted on the chosen protocol involving electromagnetic interactions, which have not been applied, due to the non-biodegradibility  of the gold or metal nanoparticles required to achieve a certain field enhancement. In the meanwhile, more than 1300 materials that have been theoretically or emperically studied to have a capability to target SARS-COV-2, have been reviewed for their capability to achieve the required electromagnetic interactions, but none of them could theoretically, at their best, provide the required interaction specifications. Moreover, and fifth, an exhaustive review for all field enhancement approaches have been reviewed in this work, as well, but none of them could be applicable in this case of concern, for detailed reasoning that has been provided in this work, too. Therefore, and sixth, a novel field enhancement approach has been designed. This approach was intended to help the entire world of drug delivery, since it is material independent, which helps with the replicability of this approach to other targeted drug delivery applications, even upon changing the targeting coating material. Furthermore, the approach is verified numerically and empirically. Seventh, not only does this work provide a novel field enhancement approach, but it sets up an unprecedented, detailed roadmap for field enhancement to facilitate and accelerate the entire world-wide research in this field. Eighth, this work applies all of the outlined protocol milestones theoretically and practically to verify it, which sets a pioneering gateway for the world of targeted drug delivery, using novel perspectives. Ninth, this work was considering the strictly limited technological capabilities  in Egypt, which is helpful in the sense of simplicity and cost-efficiency, that suit other developing countries.

Author(s) Details:

A. Q. Noha,
Department of Physics, Zewail City of Science and Technology, Giza, Egypt and Department of Electronics and Communication Engineering, Faculty of Engineering, Ain Shams University, Cairo, Egypt.


Please see the link here: https://stm.bookpi.org/AURTDDUPOGC/article/view/10225

Apoptosis - A Begining of Programmed Ending | Book Publisher International

A dysfunctional apoptotic system can lead to either excessive removal or prolonged survival of cells. Therefore, dysregulation of apoptosis is involved in the pathogenesis of a variety of diseases such as cancers, viral infections and immunological disorders. Mitochondrial physiology is disrupted in cells undergoing either apoptosis or necrosis. During apoptosis mitochondrial permeability is altered and apoptosis specific protease activators are released from mitochondria. The ability of viruses to both induce and evade apoptosis plays an important role in the pathogenesis of viral diseases. The understanding of these mechanisms is important for the elucidation of the molecular basis of viral diseases and for the development of vaccines and effective inhibitors directed against viral proteins.Author(s) Details:

Dr. Prasad Karande,
Department of Oral Pathology and Microbiology, D. Y. Patil Dental School, Lohegaon, Pune, Maharastra, India.

Dr. Abhijeet Sande,
Department of Oral Medicine and Radiology, D. Y. Patil Dental School, Lohegaon, Pune, Maharastra, India.

Dr. Nilima Karande,
Department of Prosthodontics and Crown and Bridge, Y. C. Dental College and Hospital, Ahmednagar, Maharastra, India.

Please see the link here: https://stm.bookpi.org/AABPE/issue/view/1004