Role of Bioactive Green Synthesized Nanoparticles in Various Diseases | Chapter 9 | Research Perspectives of Microbiology and Biotechnology Vol. 9

Nanoparticles (NPs) are transforming agents in biotechnology. The current strategies for diagnostics, targeted drug delivery and therapy may be offered through this transformational agent. The green synthesis of NPs, which may include those obtained from plant extracts, thereby outlining a sustainable and biocompatible approach to nanobiotechnology. This green synthesis method is much less harmful than chemical processes in the aspect of toxicity. It also makes the nanoparticle much more biocompatible and suitable for medical applications.

Gold NPs are among the most prominent examples to date and have the significant contributions in the realms of biosensing technologies: enabling early detection of infectious diseases and offering novel pathways for cancer therapy. From green synthesis, the gold NPs possess physicochemical properties that allow them to be a functionalized target delivery system, enhancing therapy efficacy while reducing the onset of side effects. Leverage the bioactive compounds found in plants to understand how such NPs may enhance the diagnosis accuracy and the effectiveness of the therapeutic approaches. Integrating sustainability in biotechnology applications has great potential by way of advancing personalized medicine in the face of environmental sustainability within the field.

 

Author (s) Details

 

Sushanta Kumar Barik
Department of Biotechnology, Institute of Biosciences and Technology, MGM University, Chhatrapati Sambhaji Nagar, Maharashtra, India.

 

Akshata Sewalikar
Department of Biotechnology, Institute of Biosciences and Technology, MGM University, Chhatrapati Sambhaji Nagar, Maharashtra, India.

Mulay Manjushree Vijay
Department of Microbiology, MGM Medical College and Hospital, Chhatrapati Sambhaji Nagar, Maharashtra, India.

 

Smita Sitaram Kulkarni
Department of Microbiology, MGM Medical College and Hospital, Chhatrapati Sambhaji Nagar, Maharashtra, India.

 

Sanjay N Harke
Department of Biotechnology, Institute of Biosciences and Technology, MGM University, Chhatrapati Sambhaji Nagar, Maharashtra, India.

 

Annasaheb S Khemnar
Department of Biotechnology, Institute of Biosciences and Technology, MGM University, Chhatrapati Sambhaji Nagar, Maharashtra, India.

 

Ashish S. Deshmukh
Department of Respiratory Medicine, MGM Medical College and Hospital, Chhatrapati Sambhaji Nagar, Maharashtra, India.

 

Sanjay J Dhoble
Department of Physics, R.T.M. Nagpur University, Nagpur-440033, India.

 

Sadanand Y Guhe
Department of Chemical Engineering, MGM’S Jawaharlal Nehru Engineering College-MGM University, Maharashtra, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/rpmab/v9/3799

Nanoparticles: Characteristics, Preparation, Applications and Challenges in Modern Technologies | Chapter 4| Pharmaceutical Science: New Insights and Developments Vol. 3

Nanoparticles have distinctive characteristics such as their particle size ranges from 1-1000 nm and exhibit special physical, chemical and biological properties and have become a future-proof technology. It has broad effects on a number of sectors including consumer goods, energy and medicine. This overview offers a thorough analysis of the many kinds of nanoparticles, such as polymeric nanoparticles, solid lipid nanoparticles, metallic nanoparticles, etc., as well as methods for preparing and assessing them. The advantages of nanoparticles include increased solubility, targeted drug delivery, enhanced bioavailability and many more. There are many applications of nanoparticles in many fields such as diagnostics, therapeutics, imaging and biosensing. However, there are even demerits of these as potential toxicity, immunogenicity, environmental impacts and even cost is also pretty high. Some of the demerits can be overcome by careful assessment of the manufacturing technique. Furthermore, necessary evaluation techniques can be considered for characterizing the size, shape, surface area and other significant characteristics of nanoparticles.

 

Author (s) Details

Saravanakumar Kasimedu
Seven Hills College of Pharmacy (Autonomous), Tirupati, Andhra Pradesh 517561, India.

 

Usha Priya Halapaka Selvam
Seven Hills College of Pharmacy (Autonomous), Tirupati, Andhra Pradesh 517561, India.

 

Keerthishree Suresh Sharma
Seven Hills College of Pharmacy (Autonomous), Tirupati, Andhra Pradesh 517561, India.

 

Navina Sreenivasan Arrivur
Seven Hills College of Pharmacy (Autonomous), Tirupati, Andhra Pradesh 517561, India.

 

Nagaveni Pommala
S.V.U. College of Pharmaceutical Sciences, Sri Venkateswara University, Tirupati, Andhra Pradesh 517502, India.

Niranjan Babu Mudduluru
Seven Hills College of Pharmacy (Autonomous), Tirupati, Andhra Pradesh 517561, India.

 

Mallikarjuna Gandla
Seven Hills College of Pharmacy (Autonomous), Tirupati, Andhra Pradesh 517561, India.

 

Prudhvi Raj Vadamala
Seven Hills College of Pharmacy (Autonomous), Tirupati, Andhra Pradesh 517561, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v3/4293

Electronic, Nonlinear Optical, Reactivity and Solubility Analysis of the Antimalarial Drug Dihydroartemisinin Functionalized on Carbon Nanotube: DFT Study | Chapter 3 | Advances and Challenges in Science and Technology Vol. 4

 The purpose of the current study search out enhance the intend distribution of the dihydroartemisinin (DHA) drug and model novel nanometric compounds for use in nanotechnologies by functionalizing DHA on the (5,5) single divider carbon nanotube (SWCNT, C60H20) promoting the 1,3-diploar cycloaddition (DC) reaction of azomethine ylide. To analyze the use of functionalized carbon nanotubes (fCNTs) as a nanovector for the engaged delivery of the antimalarial drug dihydroartemisinin, density working theory (DFT) estimates of the drug were performed in vapor phase and liquid. According to the geometric addition's findings, DHA's microscopic structure is unmoved by functionalization. Based on the findings of binding and solvation strengthes, two energetically fixed configurations were identified in 1st (fCNT1-2) and 2nd (2fCNT1-2) functionalization. For these fixed configurations, the energy break value goes from 1.52 eV for the (5,5) distinct wall clean CNT to 1.27 eV for the 1st functionalization and to 1.06 eV for the 2nd functionalization regardless of the considered publishing; which gives these nanostructures wonderful semiconductor properties. Global sensitivity descriptor results disclose that the functionalized CNT has significantly improved reactivity bankrupt conditions what the functionalization of DHA has decreased establishment while increasing responsiveness to stimuli. Thus, the fundamental gap (Ef) in vapor phase decreases from 3.65 eV for mother of jesus CNT to 3.30 eV for fCNT2 and to 3.02 eV for 2fCNT2. On the contrary, in water Ef goes from 1.20 eV for the virgin CNT to 0.95 eV for fCNT2 and to 0.74 eV for 2fCNT2; professed an improvement in the responsiveness to stimuli of the investigated fCNTs as nanovectors for targeted transfer of DHA drug. Finally, the results of this study display that these nanostructures could still have favorable NLO traits, making them conceivably useful fabrics for NLO applications.

Author(s) Details:

D. Fouejio,
Materials Science Laboratory, Department of Physics, Faculty of Sciences, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

Y. Tadjouteu Assatse,
Materials Science Laboratory, Department of Physics, Faculty of Sciences, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

R. A. Yossa Kamsi,
Materials Science Laboratory, Department of Physics, Faculty of Sciences, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

G. W. Ejuh,
Department of General and Scientific Studies, University of Dschang, IUT-FV Bandjoun, P.O. Box 134, Bandjoun, Cameroon and Department of Electrical and Electronic Engineering, National Higher Polytechnic Institute, University of Bamenda, P.O. Box 39, Bambili, Cameroon.

J. M. B. Ndjaka,
Materials Science Laboratory, Department of Physics, Faculty of Sciences, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

Please see the link here: https://stm.bookpi.org/ACST-V4/article/view/12095

An Unprecedented Revolution in Targeted Drug Delivery Using Photonics: Overcoming Global Challenges | Book Publisher International

Notwithstanding the endless efforts on targeted drug delivery, specially upon the arrisal of uncontrallable moratlity rates due to SARS-COV-2 and cancer, there has never been an FDA approved drug or a treatment approach. Therefore, this work was dedicated to find a new approach to not only treat but also to image the dynamics of SARS-COV-2. This work aimed at adding multiple aspects that constitute a significant need to science and the worldwide health experts. First, not only does it review the conventional treatment approaches such as chemical,  herbal, genetic, stem-cell based or other therapies, but the review extends, for the first time, to include all possible external triggers that could interact with SARS-COV-2. Second, a generic treatment and imaging approach is then outlined, to expand the range of benefit to all researchers who aim at continuity of study in this field. Third, and importantly, the protocol is generic to be applicable to all targeted drug delivery applications, which is detailed through the explanation of the design objectives, requirements, and a guided, evidence-oriented development of the selected protocol, which will be significant to other targeted drug delivery applications such as cancer, with a manimial changes in the dose, and coating. Fourth, exhaustive reviews have been conducted on the chosen protocol involving electromagnetic interactions, which have not been applied, due to the non-biodegradibility  of the gold or metal nanoparticles required to achieve a certain field enhancement. In the meanwhile, more than 1300 materials that have been theoretically or emperically studied to have a capability to target SARS-COV-2, have been reviewed for their capability to achieve the required electromagnetic interactions, but none of them could theoretically, at their best, provide the required interaction specifications. Moreover, and fifth, an exhaustive review for all field enhancement approaches have been reviewed in this work, as well, but none of them could be applicable in this case of concern, for detailed reasoning that has been provided in this work, too. Therefore, and sixth, a novel field enhancement approach has been designed. This approach was intended to help the entire world of drug delivery, since it is material independent, which helps with the replicability of this approach to other targeted drug delivery applications, even upon changing the targeting coating material. Furthermore, the approach is verified numerically and empirically. Seventh, not only does this work provide a novel field enhancement approach, but it sets up an unprecedented, detailed roadmap for field enhancement to facilitate and accelerate the entire world-wide research in this field. Eighth, this work applies all of the outlined protocol milestones theoretically and practically to verify it, which sets a pioneering gateway for the world of targeted drug delivery, using novel perspectives. Ninth, this work was considering the strictly limited technological capabilities  in Egypt, which is helpful in the sense of simplicity and cost-efficiency, that suit other developing countries.

Author(s) Details:

A. Q. Noha,
Department of Physics, Zewail City of Science and Technology, Giza, Egypt and Department of Electronics and Communication Engineering, Faculty of Engineering, Ain Shams University, Cairo, Egypt.


Please see the link here: https://stm.bookpi.org/AURTDDUPOGC/article/view/10225