The goal of the current review paper is to discuss new developments investigated for colonic delivery system in-vitro and in-vivo assessment methodologies and their prospective pharmaceutical uses. Colon focused medication delivery systems are created in a way that by-passes the gastro intestinal (GI) tract's upper hostile bio-environment while directly releasing material into the colonic area exclusively. This article focuses on in-vitro and in-vivo assessment techniques that can prove a delivery system's resistance to attacks on the upper bio-environment of the GI tract, such as GI motility, pH shifts from an acidic to an alkaline medium, fluid contents, gastro enzymatic activity, etc. These stated assessment metrics support the effective development of medication delivery systems for colon-specific targeting and assist us in overcoming formulation restrictions. The use of a few polysaccharides as excipient materials for the creation of several colon-targeted medications was also a major focus of this research.
Reena Kaushik,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) - 495009, India.
S. K. Lanjhiyana,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) - 495009, India.
Sanmati K. Jain,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) - 495009, India.
Sweety Lanjhiyana,
School of Pharmacy, Chouksey Engineering College, Bilaspur (C.G.) - 495001, India.
A. C. Rana,
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India.
Please see the link here: https://stm.bookpi.org/CAPR-V4/article/view/7510
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