The goal of a recent review paper is to investigate the variables that influence designing and formulation strategies for the creation of possible colon-specific drug delivery systems. These variables had an impact on the general pattern of drug release from the delivery systems, as well as on drug absorption and bioavailability at the site of effects. Additionally, the function and effects of those inert polymers that were included into formulations as a matrix or reservoir are discussed. Drug delivery methods that target the colon have the potential to cure a wide range of illnesses, including Crohn's disease, ulcerative colitis, irritable bowel syndrome, and colon cancer. Over the previous few decades, According to findings from several researchers, the colonic area has the potential for effective local and systemic medication absorption. The gastrointestinal (GI) anatomy and physiology, pH variations, presence of microorganisms, transit duration, fluid volume, etc. of the human body all have an impact on these methodology-based delivery systems. This article discusses a few strategies that have been investigated for developing dosage forms that target the colon and comprise pharmacological candidates that can be used for all potential therapeutic advantages.
Reena Kaushik,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, (C.G.) - 495009, India.
S. K. Lanjhiyana,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, (C.G.) - 495009, India.
Sanmati K. Jain,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, (C.G.) - 495009, India.
Sweety Lanjhiyana,
School of Pharmacy, Chouksey Engineering College, Bilaspur, (C.G.) - 495001, India.
A. C. Rana,
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India.
Please see the link here: https://stm.bookpi.org/CAPR-V4/article/view/7511
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