The current article's goal is to investigate colon-specific delivery methods and the variables that determine how well drug candidates are delivered to the relevant pharmacological locations. The colon has demonstrated to be a location where medication candidates can be effectively absorbed locally, topically, and systemically. It adopts the preferred oral route for patient compliance and has less systemic adverse effects. This method of medicine delivery is preferable over the painful rectal route, which has lower patient compliance rates. The anatomy and physiology of the colon, colonic pH, colonic flora, GI transit time, fluid quantities, formulation parameters, etc. are some of the variables impacting colon delivery. The use of a colon-specific delivery method for treating disorders like colonic cancer, amebiasis, Crohn's disease, ulcerative colitis, etc. enables drugs to be sent directly to the intended site of action. Direct drug administration into the colon utilising matrix or reservoir-based delivery systems is achievable because these systems can defend themselves against attacks from the stomach's acidic and small intestinal's alkaline environments.
Reena Kaushik,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) - 495009, India.
S. K. Lanjhiyana,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) - 495009, India.
Sanmati K. Jain,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) - 495009, India.
Sweety Lanjhiyana,
School of Pharmacy, Chouksey Engineering College, Bilaspur (C.G.) - 495001, India.
A. C. Rana,
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India.
Vipul Kumar,
Delhi Institute of Pharmaceutical Sciences and Research, New Delhi-110017, India.
Please see the link here: https://stm.bookpi.org/CAPR-V4/article/view/7509
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