Metabolic syndrome is a progressive condition characterised by central obesity, hypertension, dyslipidemia, hyperglycemia, and insulin resistance. Patients with metabolic syndrome are more likely to die from heart disease, stroke, vascular dysfunction, and other reasons. Obesity is one of the most serious epidemics of our day, and the hormone leptin is crucial for maintaining body weight and energy balance. The goal of this study was to determine the significance of leptin as a biomarker in the metabolic syndrome.
Methods: A total of 355 participants from the ESIC hospital's Okhla OPD, Department of General Medicine, were chosen for the study, with 196 men and 159 women suffering from type 2 diabetes mellitus and metabolic syndrome. From June 2018 to July 2019, data was collected over the course of a year. After a baseline clinical and anthropometric evaluation, the patients' FBS, PPBS, lipid profile, Insulin (fasting), and leptin levels were examined.
Female patients with type 2 diabetes and metabolic syndrome exhibited significantly higher fasting, postprandial, lipid profile, leptin, and insulin levels than male patients with the same conditions. Conclusions: Leptin has a significant link with metabolic syndrome, according to the data, and could be used as a biomarker for early detection of the disease.
Author (S) Details
Juhi Aggarwal
Department of Biochemistry, Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh, India.
Niharika Singh
Department of Biochemistry, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh, India.
Mayur Kumar
Department of Biochemistry, Specialist Grade II, ESIC Hospital, Okhla Industrial Area, Delhi, India.
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