The Role of Modern Media in Preserving African Moral Values and Promoting Economic Development in Ghana | Chapter 8 | New Advances in Business, Management and Economics Vol. 3

In the modern era of globalisation, the media have become a powerful tool that surpasses physical borders, facilitating the flow of ideas, information, and cultural manifestations around the globe. This paper delved into the effects of modern media on the preservation of traditional African moral values and economic development in Ghana. The paper is purely qualitative and relies mainly on related literature. Content and thematic analyses were employed. It was revealed that radio and television, especially in African contexts, serve as mediums for passing down cultural norms, values, and practices. The impact of modern media on moral ideals and cultural practices in sub-Saharan Africa is subject to variation depending on socio-economic conditions, rates of urbanisation, and levels of technical accessibility. By showcasing traditional music, storytelling, and other cultural elements, media platforms contribute to maintaining a sense of continuity in cultural identity. The ability to convey perceptions, hopes and dreams unrestricted on these platforms enables Africans to actively participate in shaping their cultural narrative. It was revealed that increased media consumption correlates with a rise in support for Lesbian, Gay, Bisexual, Transgender, Queer, or Questioning, Intersex, Asexual and More (LGBTQIA+) rights in Africa. Also, media can be used as a tool for exacerbating hate speech and propaganda. Media literacy programmes and public awareness campaigns can educate citizens about media's influence and encourage critical thinking. Education systems should integrate cultural education highlighting traditional values, history, and practices into the academic curriculum. Academic institutions should invest in research to continuously monitor media's impact on cultural values and economic development. In conclusion, the findings have shown that the media and the showcase of foreign media content have had both positive and negative effects on the economic development and preservation of Ghanaian and African traditional moral values.

 

Author (s) Details

 

Thomas Azagsiba Agana
Simon Diedong Dombo University of Business and Integrated Development Studies, Ghana.

 

Michael Pervarah
Simon Diedong Dombo University of Business and Integrated Development Studies, Ghana.

 

Lawrence Naaikuur
Simon Diedong Dombo University of Business and Integrated Development Studies, Ghana.

 

Please see the book here:- https://doi.org/10.9734/bpi/nabme/v3/4207

Assessing the Impact of Income Inequality on Poverty Level in Nigeria Using Auto Regressive Distributed Lag Model | Chapter 7 | New Advances in Business, Management and Economics Vol. 3

There is widespread concern about global inequality and economic growth that the economic crisis has only widened the gap between the rich and the poor. Poverty and income inequality are two interrelated and mutually reinforcing developmental issues in Africa. This research employed the Auto Regressive Distributed Lag (ARDL) model to evaluate the influence of income inequality on the level of poverty in Nigeria. The secondary data from CBN (2011) and WDI (2022) was used in this study. The study's findings indicated a sustained positive correlation between poverty levels and the Gini coefficient of income inequality in Nigeria, derived from the relationship of each income determinant with the Gini coefficient of income disparity in the Nigerian economy. Therefore, it is advisable to improve the equitable distribution of resources, which will effectively diminish economic inequality and poverty in Nigeria. The government ought to focus on formulating and executing more pragmatic employment initiatives in Nigeria. The empirical findings of this study indicate that reducing income inequality in Nigeria by an increase in the employment rate has been inadequate. A pragmatic approach to employment would enable individuals to utilise their finances to accumulate wealth rather than merely subsist, hence enhancing the degree of the income distribution.

 

Author (s) Details

Sule Magaji
Department of Economics, University of Abuja, Nigeria.

 

Ibrahim Musa
Department of Economics, University of Abuja, Nigeria.

 

Yahaya Ismail
Department of Economics, University of Abuja, Nigeria.

 

Please see the book here:- https://doi.org/10.9734/bpi/nabme/v3/1480

Striking the Balance: Navigating the Complexities of Intrauterine Infection and Inflammation (Triple I) for Better Maternal and Neonatal Outcomes | Chapter 10 | Disease and Health: Research Developments Vol. 5

Intrauterine infection, inflammation or both (Triple I) is known to cause detrimental pregnancy outcomes. On one hand delay in the diagnosis of chorioamnionitis can potentially cause adverse pregnancy outcomes, on the other hand, over-diagnosis leads to inapt antibiotic use, prolonged neonatal intensive care unit (NICU) stay, disruption of mother-infant bonding, delays in breastfeeding, economic burden and emotional stress from the prolonged hospital and NICU stay. In the literature, many studies and reviews have discussed Triple I in detail. However, many issues with diagnosis and management remain unclear. This narrative review gives an insight into  these issues and will aid not only in the diagnosis but also in the management of Triple-I.

 

Author (s) Details

 

Sufia Athar
Al Wakra Hospital, Hamad Medical Corporation, Qatar and Qatar University, Qatar.

 

Sarfaraz Abedin
Al Wakra Hospital, Hamad Medical Corporation, Qatar.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v5/4277

Minimal Brain Dysfunction (MBD) and its Impact on Musculoskeletal Deformities: Causes, Symptoms and Physiotherapy Interventions | Chapter 9 | Disease and Health: Research Developments Vol. 5

Some children’s “muscular-skeletal system” disorders can be seen early in newborns and babies. They are symptoms of Minimal Brain Dysfunction (MBD). These abnormalities are caused by an asphyxia of the fetus during pregnancy or delivery. This study discusses Minimal Brain Dysfunction (MBD) and Its Impact on Musculoskeletal Deformities. This study also discusses the causes, symptoms, and physiotherapy interventions of MBD. Among various disorders of the locomotor system in children and also in youth patients, there are changes connected with the functioning of the Central Nervous System. Children with MBD have also psychological changes in their behavior. In the diagnosis, it is important to inquire about the gravidity and the delivery. Early therapy is the best prophylaxis of pain syndromes and arthrosis of the feet, knees, hips, and spine in adults.

 

Author (s) Details

 

Tomasz Karski
Vincent Pol University of Lublin, Poland.

 

Jacek Karski
Paediatric Orthopaedic and Rehabilitation, Department of Medical, University of Lublin, Poland.

 

Klaudia Karska
Department of Paediatric Radiology of Medical University of Lublin, Poland.

 

Paul Ochen
Ogojoi Rehabilitation Care Center, Soroti, Uganda.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v5/4201

Achievement of a UV Photodetector Based on TiO2/CuMnO2 Heterostructures: A New Strategy | Chapter 8 | Chemical and Materials Sciences: Developments and Innovations Vol. 10

Recently, UV sensors and photodetectors have drawn growing attention due to their wide applications in environmental safety, biological research, medicine, gas sensors, optical communication, astronomical studies, space exploration, etc. Within this paper, a UV photodetector based on n-type TiO₂ and p-type CuMnO₂ heterojunction was successfully achieved using a simple, reproducible and cost-effective two-step method: thermal oxidation growth of TiO₂ layers on titanium foil and deposition of CuMnO₂ thin films by the Doctor Blade technique, respectively. To investigate the structural and morphological properties of the as-synthesized heterostructures, XRD, SEM/EDX and AFM techniques were used. Therefore, XRD analysis confirmed the phase stability and purity of the structures, while SEM and AFM revealed the uniform coverage of CuMnO₂ on the polyhedral TiO₂ surface. Based on Mott-Schottky results, the optoelectronic performance and the flat band potential are influenced by the thickness and roughness of the TiO₂ layer. Electrical measurements demonstrated a diode-like behavior with the turn-on voltage increasing proportionally to the structure of the TiO₂ layer, therefore the S2a sensor showed optimal performance with a UV sensitivity of 4.99, a response capacity of 100.6 mA mW⁻¹ cm², and a fast response time of 1.56 s. The results indicate that the proposed heterojunction offers a promising solution for selective and efficient UV light detection systems. In conclusion, UV photodetectors based on n-TiO₂ and a p-CuMnO₂ heterojunction were successfully obtained via a simple, reproducible and inexpensive method, and have great potential applications in light detection systems.

 

Author (s) Details

 

Mircea Nicolaesc
Condensed Matter Department, National Institute for Research and Development in Electrochemistry and Condensed Matter, 300224 Timisoara, Romania and Department of Applied Chemistry and Engineering of Inorganic Compounds and Environment, Politehnica University of Timisoara, 300223 Timisoara, Romania.

 

Corina Orha
Condensed Matter Department, National Institute for Research and Development in Electrochemistry and Condensed Matter, 300224 Timisoara, Romania.

 

Mina-Ionela Morariu (Popescu)
Condensed Matter Department, National Institute for Research and Development in Electrochemistry and Condensed Matter, 300224 Timisoara, Romania and Department of Applied Chemistry and Engineering of Inorganic Compounds and Environment, Politehnica University of Timisoara, 300223 Timisoara, Romania.

 

Viorel Serban
Department of Materials and Manufacturing Engineering, Faculty of Mechanical Engineering, University Politehnica of Timisoara, Mihai Viteazu Street, No. 1, 300222 Timisoara, Romania.

 

Simona Caprarescu
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania.

 

Carmen Lazau
Condensed Matter Department, National Institute for Research and Development in Electrochemistry and Condensed Matter, 300224 Timisoara, Romania.

 

Cornelia Bandas
Condensed Matter Department, National Institute for Research and Development in Electrochemistry and Condensed Matter, 300224 Timisoara, Romania.

 

Please see the book here:- https://doi.org/10.9734/bpi/cmsdi/v10/4345

One Idea for Preparation of Solidified Oxide Eutectic Film by Controlling Chemical Reaction between the Melt and Substrate | Chapter 7 | Chemical and Materials Sciences: Developments and Innovations Vol. 10

A preparation method for solidified eutectic film with good adhesion between the film and substrate by controlling the chemical reaction between the base material and the melt is described. As an example, Al₂O₃-HfO₂ eutectic solidification film was formed on a SiC substrate. Al₂O₃-HfO₂ eutectic EBC film is prepared by the optical zone melting method on the silicon carbide substrate. At high temperatures, a small amount of silicon carbide decomposes into silicon and carbon. The components of Al₂O₃ and HfO₂ in the molten phase also react with the free carbon. The Al₂O₃ phase reacts with free carbon, leading to the formation of AlO vapor species. The composition of the molten phase becomes HfO₂ rich from the eutectic composition. HfO₂ phase also reacts with the free carbon and HfC phase is formed on the silicon carbide substrate; then a high-density intermediate layer is formed. The adhesion between the intermediate layer and the substrate is excellent by an anchor effect. When the solidification process is finished before all of the HfO₂ phase is reduced to the HfC phase, HfC-HfO₂ functionally graded layer is formed on the silicon carbide substrate and the Al₂O₃-HfO₂ eutectic structure grows from the top of the intermediate layer. This process can be applied to different oxide eutectic systems that include HfO₂ and/or ZrO₂ phase such as CaZrO₃-ZrO₂ and Ln₂Zr₂O₇-ZrO₂ eutectic systems.

 

Author (s) Details

 

Kyosuke Seya
College of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan.

 

Shunkichi Ueno
College of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan.

 

Byung-Koog Jang
National Institute for Materials Science, Tsukuba, Ibaraki 305-0047, Japan.

 

Please see the book here:- https://doi.org/10.9734/bpi/cmsdi/v10/4326

Meconium Proteins as Potential Biomarkers for Fetal Iron Status and Intrauterine Inflammation | Chapter 13 |Disease and Health: Research Developments Vol. 4

The lack of specific biological materials and biomarkers limits our knowledge of the mechanisms underlying intrauterine regulation of iron supply to the fetus. Determining the meconium content of proteins functionally related to the regulation of iron metabolism may explain their role in fetal development. This study assesses the homeostasis of iron metabolism in intrauterine fetal development by determining the concentrations and interdependencies in neonatal meconium proteins commonly recognized in laboratory diagnostics for the assessment of iron status. Ferritin, transferrin, haptoglobin, ceruloplasmin, lactoferrin, myeloperoxidase (MPO), neutrophil gelatinase-associated lipocalin (NGAL), and calprotectin were determined by ELISA in meconium samples obtained from 122 neonates. Statistical analysis was performed by using Statistica Version 13 (StatSoft Inc., TIBCO Software Inc., Palo Alto, CA, USA). There were strong correlations between the meconium concentrations of haptoglobin, transferrin, and NGAL (p < 0.05). Meconium concentrations of ferritin were several-fold higher than the concentrations of the other proteins, with the exception of calprotectin whose concentration was approximately three-fold higher than that of ferritin. Meconium ceruloplasmin concentration significantly correlated with the concentrations of MPO, NGAL, lactoferrin, and calprotectin. Strong correlations between specific proteins in meconium, such as haptoglobin, transferrin, and NGAL, suggest their collaborative involvement in iron homeostasis within the fetus. Furthermore, the study's findings provide valuable information about the potential role of ceruloplasmin in regulating neutrophil activity in the intrauterine environment.

 

Author (s) Details

 

Ewa Skarzynska
Department of Laboratory Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland

 

Artur Jakimiuk
Department of Obstetrics, Women’s Diseases and Gynecologic Oncology, National Medical Institute of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland and Center for Reproductive Health, Institute of Mother and Child, 01-211 Warsaw, Poland.

 

Tadeusz Issat
Department of Obstetrics and Gynecology, Institute of Mother and Child, 01-211 Warsaw, Poland.

 

Barbara Lisowska-Myjak
Department of Biochemistry and Pharmacogenomics, Medical University of Warsaw, 02-097 Warsaw, Poland.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v4/4167

Impact of BMI on Adiponectin, Resistin, and Fasting Blood Glucose in Type 2 Diabetic Women | Chapter 12|Disease and Health: Research Developments Vol. 4

Background: Obesity has emerged as a public health crisis in many populations including Sudanese. Adipose tissue produces several adipokines, one of them is adiponectin which has attracted much attention due to its anti-diabetic and anti-atherogenic effects. Adipose tissue is a key endocrine organ that communicates with the brain, muscles, liver, and pancreas, thereby maintaining energy homeostasis. Obesity is a frequent comorbidity in patients with type 2 diabetes mellitus (T2DM) and it has been estimated that at least 90% of these patients are overweight or obese (Alberti et al., 2005). The risks of many complications and comorbidities (e.g., cardiovascular disease and chronic kidney disease) are considerably increased in patients with T2DM who have concomitant obesity.

 

Aim: This study aims to evaluate the level of Resistine, Fasting Blood Glucose and Adiponectin in overweight, obese versus normal weight females and compare with the BMI.

 

Methods: A descriptive cross-sectional-case-control study, the target population, is a total of 204 Sudanese females that were recruited to participate in this study (102 overweight, obese versus 102 non-overweight, and non-obese), aged 20-50 years and venous blood samples were collected. Plasma levels of blood glucose were measured using the particle-enhanced immunoturbidimetric assay method Cobas C-311®, while adiponectin and resistine were estimated by ELISA Kits. Anthropometric measurements, including height and weight, were taken using standard protocols. BMI was calculated as weight (in kilograms) divided by height (in meters squared). The mean and SD were obtained, and "t"-test and one-way analysis of variance (ANOVA) were used for comparison. Linear regression was also used for correlation. p-value was obtained to assess the significance of the results (p < 0.05 was significant).

 

Results: According to these, results observed significant differences between the means of FBG, adiponectin, resistine, and BMI compared with normal weight, overweight, and obese respectively. (FBG in normal weight (127 ± 16.7), FBG in over weight (153 ± 19.2), FBG in obese (189 ± 22.7), P = 0.037, adiponectin in normal weight (11.2 ± 1.9), adiponectin in over weight (9.7 ± 1.6), adiponectin in obese (6.1 ± 1.5), P = 0.043, resistine in normal weight (12.8 ± 1.1), resistine in over weight (14.2 ± 2.7), resistine in obese (18.2 ± 2.9), P = 0.021, BMI in normal weight (18.3 ± 1.7), BMI in over weight (26.1 ± 2.2), BMI in obese (30.4 ± 3.7), P = 0.006). In this study, the results show a strong negative correlation between the levels of serum adiponectin and FBG, adiponectin, and resistine (p = 0.013, r = -7.9) (p = 0.019, r = -6.6), while showing in the other side strong positive correlation between the levels of serum resistine and FBG (p = 0.015, r = 6.0).

 

Conclusion: The findings suggested that, in patients diagnosed T2DM, adipocytokine concentrations (resistin and adiponectin) differed between patients who had normal BMI and those who were obese. This study concluded that the level of Resistine and Fasting Blood Glucose increased and Adiponectin was reduced in obese compared to non-obese females, Diabetic Patient Type2.

 

Author (s) Details

Salah Eldin Omar Hussein
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.

 

Abd Elgadir Alamin Altoum
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.

 

Ahmed L. Osman
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.

 

Hassan M. K. I. Higazi
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.

 

Sara Ali
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.

 

Ayman Hussien Alfeel
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v4/3915

Knowledge and Practice of Documentation in Labour among Healthcare Professionals in a Tertiary Healthcare Facility, South- South, Nigeria | Chapter 11 | Disease and Health: Research Developments Vol. 4

Background: Documentation is a fundamental and vital communication tool among healthcare professionals. It is an essential part of nurse/ midwife that has clinical and legal implications for the client nurse/ midwife as well as the health care institution. This study assessed determinants of documentation in labour among healthcare professionals in a tertiary healthcare facility in South-South, Nigeria.

 

Methods: This is a descriptive cross-sectional study with a sample size of 102 purposively selected healthcare professionals (nurses/midwives). The instrument for data collection was self-structured questionnaire. Data collected were analysed using statistical package for social sciences (SPSS) version 23 and presented in simple percentage and frequency table.

 

Results: The findings of the study showed that nurses had good knowledge of documentation in labour. Determinant factors influencing documentation includes; time, their poor attitude towards documentation (terming documentation to be unnecessary), and few number of midwives working in a shift.

 

Conclusions: Findings concluded that respondents have good knowledge of documentation, however this has not translated into practice. Also, there are factors that influence this practice among the respondents.

 

Recommendations: It was recommended that training and workshops on the importance of documentation should be organized regularly to create more awareness on documentation; to encourage and promote its practice; identify factors hindering its use as well as provide strategies for overcoming these factors. Also, more staff should be assigned to clients and the shift adjusted to shorter hours to prevent fatigue and tediousness.

 

Author (s) Details

 

Maureen Dike Frank
Department of Nursing Science, Faculty of Basic Medical Sciences, College of Medical Sciences, Rivers State University, Nigeria.

 

Paulina Ackley Akpan-Idiok
Department of Nursing Science, Faculty of Allied Health Sciences, College of Health Sciences, University of Uyo, Uyo, Akwa Ibom State, Nigeria.

 

Chukwu Chinenye
Department of Nursing Sciences, Madonna University, Nigeria.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v4/3225

MPO-ANCA Positivity in IgA Nephropathy: Deceptor or Consequence? | Chapter 10 | Disease and Health: Research Developments Vol. 4

Background: Immunoglobulin A (IgA) nephropathy is the most prevalent primary glomerulonephritis (GN). Antineutrophil cytoplasmic-associated vasculitis (AAV) is the most common cause of rapidly progressive crescentic GN. IgA nephropathy is the most common primary glomerulonephritis, while the most common cause of rapidly progressive glomerulonephritis (RPGN) is pauci immune crescentic glomerulonephritis (GN), followed by Immune complex-mediated GN and anti-Glomerular basement membrane (GBM) disease. Anti-neutrophil cytoplasmic autoantibody (ANCA) is characterised by crescentic necrotizing GN on renal biopsy with minimal deposits. Immunoglobulin A (IgA) nephropathy may present as crescentic GN with mesangial IgA deposits and sometimes around capillary as well. The co-existence of circulating ANCA in a patient of IgA nephropathy with RPGN presentation is a rare phenomenon and very little literature is available on the same.

 

Case Presentation: This case describes a rare presentation of RPGN which was myeloperoxidase (MPO) positive on enzyme immunoassay (EIA) with central nervous system (CNS) vasculitis presenting as hemiparesis. The patient was treated with ANCA vasculitis, with plasmapheresis (PLEX) and Cyclophosphamide as the Standard of care as KDIGO suggests the treatment may be initiated without biopsy when the presence of RPGN picture with circulating ANCA. However, renal biopsy, later revealed features of crescentic IgA nephropathy but the presence of systemic symptoms makes IgA nephropathy as the sole diagnosis highly unlikely, hence the possibility of MPO IgA concurrence remains high. Hence our case was treated in the lines of ANCA vasculitis with IV cyclophosphamide according to EUVAS protocol. Our case is at sustained remission at 6 months after 10 doses of cyclophosphamide as SOC and has now been shifted to maintenance therapy on Azathioprine (Aza), given the possibility of relapse.

 

Conclusion: Hence MPO ANCA vasculitis and IgA nephropathy is a very rare concurrence. The presence of CNS vasculitis in this background is never reported. However, this case drastically improved with Pulse cyclophosphamide and corticosteroids. Further investigations are needed to study the role of ANCA in the development and progression of IgAN, whether the presence of ANCA is merely coincidental or the damage caused by IgAN results in neutrophil priming and generation of ANCAs.

 

Author (s) Details

Pallavi Mahato
Department of Nephrology, IPGME&R, Kolkata, India.

 

Atanu Pal
Department of Nephrology, IPGME&R, Kolkata, India.

 

Souvik Ghatak
Department of Nephrology, IPGME&R, Kolkata, India.

 

Gopambuj Singh Rathod
Department of Nephrology, IPGME&R, Kolkata, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/dhrd/v4/3164

Strategies for Cultivating Healthy Workplaces in the IT Industry: A Comprehensive Examination of HR Dynamics | Chapter 31 | Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

Background: In modern society, the IT sector plays a pivotal role in driving innovation, connectivity, and efficiency across various industries. In the fast-paced landscape of the Information Technology (IT) industry, the pursuit of strategies to foster healthy workplaces is a critical imperative.

Aims: This research aims to examine the impact of workplace stress on employee productivity and mental well-being in the Information Technology (IT) industry, specifically focusing on companies in Mysuru city. It also seeks to propose and evaluate strategies for creating a healthy workplace environment within this sector.

Research Methodology: The study adopts a descriptive research approach, conducting a comprehensive literature review to understand existing theories and practices related to building healthy workplaces in the IT industry. Simple random sampling is employed to select 150 IT employees from 6 major IT companies in Mysuru city. Data is collected using a structured questionnaire and analyzed using descriptive statistics, ANOVA, and a 5-point Likert scale to unravel patterns, trends, and variations in workplace dynamics. Additionally, company-wise analysis is conducted to assess the impact of various workplace strategies.

Results: The findings indicate that workload intensity remains consistent across age groups, and there are no significant gender-based disparities in various workplace stressors. However, flexible work arrangements and mental health programs exhibit significant variations among companies, highlighting the need for tailored wellness initiatives. Age-neutral and gender-inclusive strategies are recommended to foster a healthier work environment.

Conclusion: This research underscores the importance of addressing workplace stress in the IT industry and emphasizes the need for customized wellness initiatives tailored to the unique dynamics of each organization. Moving forward, future research could explore the effectiveness of specific interventions to provide actionable guidelines for enhancing employee well-being and productivity in the evolving IT industry.

 

Author (s) Details

 

Manoj Kumara N V
Department of Management Sciences, Maharaja Institute of Technology Mysore, India.

 

Nithyashree K R
Department of Management Sciences, Maharaja Institute of Technology Mysore, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH31

Revolutionizing Retail Operations: AI and ML Implementation | Chapter 30 | Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

Aim: This paper highlights the transformative influence of the integration of artificial intelligence (AI) and machine learning (ML) technologies on the retail landscape in India, focusing on their role in enhancing customer experiences, driving sales, and reshaping retail operations and raising awareness about the ethical considerations associated with the integration, for sustainable growth and customer trust.

Methodology: Systematic review research is conducted to analyse and collect data from scholarly research databases and industry analysis. Selected research papers and reports were scrutinized, and the analysis considered their research design analysis, methodologies utilized, and data sources, to provide a comprehensive overview of the use of AI and ML in retail commerce.

Findings: The transformative capacity of Artificial Intelligence (AI) and Machine Learning (ML) within the retail sector is discussed in the findings. AI and ML technologies have a strong and deep ability to enrich user experiences through personalized recommendations, optimize inventory management, streamline supply chains, implement efficient pricing strategies, and enhance consumer service. The study discusses the limitations and scope for ethical considerations during the integration of AI and ML within the retail landscape.

Conclusion: This study emphasizes the importance of AI and ML in shaping the future scope of the retail landscape. By discussing the disruptive potential, and ethical implications of AI and ML technology integration, it provides invaluable insights to retailers, policymakers, and industry stakeholders, urging them towards continued exploration and investment in the retail ecosystem.

 

Author (s) Details

Lakshmi. H
Department of Management Studies, NITTE Meenakshi Institute of Technology, Bangalore, India.

 

Keerthi H K
Department of Management Studies, NITTE Meenakshi Institute of Technology, Bangalore, India.

 

Shilpa Ajay
Department of Management Studies, NITTE Meenakshi Institute of Technology, Bangalore, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH30

The Role of Microfinance in Driving Economic Growth and Financial Inclusion in India | Chapter 29 | Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

Finance is the foundation of the economic development of a country. Financial activities contribute to the growth of a country’s economy. India has transformed the entire financial sector with the introduction of inclusive finance, digitization and other regulations and has become an excellent financial service provider. However, it is still difficult to popularize rural finance practices. Microfinance is crucial in addressing the financial requirements in backwoods communities. It is also instrumental in the emergence of Self-Help Groups (SHGs), small business owners and new entrepreneurs. Microfinance integrates the financial services system by identifying its target customers and preparing financial products according to the exigency of the unorganized sector. Presently, microfinance has grown by 21% in FY2023 (FY2023) compared to FY2022 (FY2022). This study focuses on the play of microfinance in providing adequate finance to various sectors of the unorganized sector in India and facilitating economic growth.

 

Author (s) Details

 

Dhanalakshmi C
Acharya Institute of Technology, Bengaluru, India.

Rohith B
Acharya Institute of Technology, Bengaluru, India.

 

Bhavya V M
Acharya Institute of Technology, Bengaluru, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH29

Emerging Technologies Transforming the HR Landscape | Chapter 28 | Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

The field of Human Resources has seen considerable changes due to the rapid growth of technology, which has transformed traditional HR methods and processes. In the framework of developing technologies like as chatbots, blockchain, augmented reality, virtual reality, robotic process automation, natural language processing, and artificial intelligence, this study examines the changing landscape of HR management. The first section of the article traces the development of HR technology. After that, it looks at how HR technology is now being adopted and highlights how upcoming technologies have the ability to completely change a range of HR operations. The article investigates the effects of emerging technologies on important HR tasks like hiring and talent acquisition, employee training and development, performance management and feedback, and employee engagement and experience through detailed scrutiny. While recognizing the potential that emerging technologies offer, the study also addresses the difficulties in implementing them. There is a need for more studies on the ethical implications of AI and the impact of various AI technologies for long-term sustainability could be the area of focus. Future directions for HR technology are covered in this study, along with its effects on the workplace. The significance of ongoing learning and adaptability for HR professionals is emphasized. It ends by highlighting how new technologies have the ability to completely change the HR environment and how businesses must embrace innovation in order to be competitive in the rapidly changing digital economy.

 

Author (s) Details

 

Immaculate Joseph Kirthika
Visvesvaraya Technological University, Belagavi, India.

 

Harshini S
Visvesvaraya Technological University, Belagavi, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH28

Social Media and Emotional Intelligence: A Modern-Day Interplay among College Students | Chapter 27 | Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

Aim: To study the influence of social media on the Emotional Intelligence of college students.

Methodology: A convenient sampling method was used with 150 postgraduate college students from selected colleges in Bangalore, of which 78 were male and 72 were female. A survey instrument was developed to study the influence of social media on Emotional Intelligence, focusing on the self-management construct of the Emotional Competence Inventory (ECI). The instrument contained 22 variables across the 6 dimensions of the self-management construct and was administered online through Google Forms. The instrument achieved a reliability score of 0.9. Sixty-six hypotheses were formulated for one-sample t-tests, independent sample t-tests, and MANOVA.

Results: The one-sample t-test results highlighted that the sample mean values of all the variables were higher than the test value and significant (maximum mean difference of 1.352 at P=0.000). The independent sample t-test showed no significant difference in perceptions between male and female respondents. Similarly, no significant difference was found in the perception of respondents regarding the influence of social media on emotional intelligence based on the duration of social media use.

Conclusion: The usage of social media has a positive influence on the self-awareness and self-management of college students. Instagram, WhatsApp, and YouTube were the most used social media platforms. The top reasons for usage included knowledge and skill development, personal and professional networking, and entertainment. Further studies are necessary to explore the influence of social media on social awareness and social skills constructs of ECI. The influence can also be studied more deeply using other established instruments of emotional intelligence.

 

Author (s) Details

 

Anitabai
Department of MBA, Acharya Institute of Technology, Bengaluru, Karnataka, India.

 

Susheela Devi B Devaru
Department of MBA, Dr. Ambedkar Institute of Technology, Bengaluru, Karnataka, India.

Anju A Nair
Department of MBA, Acharya Institute of Technology, Bengaluru, Karnataka, India.

 

Archana Vijay
Department of MBA, Acharya Institute of Technology, Bengaluru, Karnataka, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH27

Driving Financial Inclusion in Bharat's Amrit Kaal: The Role of Digital Payment Platforms and Embedded Finance | Chapter 26 | Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

The 21st century is the century of technological advancement, in the context of the modern world people prefer everything under one roof. They don’t want to go to different places to get different products and services. There is a time when people prefer to stand in a queue to deposit money in a bank; those days are gone as technology advances to the next level. Digital wallets almost replaced cash transactions and India is in the phase of becoming a cashless economy. Embedded finance is financial services offered by non-financial companies such as bill payment, recharge, and money transfers etc., Here the companies which provide such services do not necessarily mean to be in the finance industry. Some of the best examples of embedded finance include PhonePe, Google Pay, Paytm, Amazon Pay etc.,

This study focused on the effectiveness and expansion of embedded finance in India using trend and comparative analysis and provided an analysis of how digitization changed every aspect of the Indian economy. The study completely depends on secondary data gathered from various websites, journals and research articles. The study concludes that the growth of embedded finance has added strength to the Indian economy by enhancing the availability of financial services at the fingertips.

 

Author (s) Details

 

Rohith B
Department of MBA, Acharya Institute of Technology, Soladevanahalli, Bengaluru – 560107, India.

Channakeshava H C
BMSIT, Doddaballapur Main Rd, Yelahanka, Bengaluru - 560064, India

 

Bhavya VM
Department of MBA, Acharya Institute of Technology, Soladevanahalli, Bengaluru – 560107, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH26

A Study on Benefits Associated with Brand in the Purchase of Mysore Silk Saree | Chapter 25 | Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

Introduction: A Mysore Silk Saree is a very unique and enjoyable purchase for customers since it embodies a weaving of both material and intangible advantages. These sarees are of high quality and are expertly woven with finest silk, which ensures both durability and opulent aesthetics. Customer relationship management is crucial for the business of Mysore silk sarees because it focuses on maintaining a strong market presence while prioritizing customer satisfaction and accordingly the customer is turning into a key factor for the little and huge organizations.

Aims and objectives: This research paper aims to study the complex relationship between consumer preferences, brand influence, and the traditional realm of buying Mysore silk sarees. It covers the relationship with business partners, regulators and investors and society in large. The aim of the study is also investigate customer behaviors and opinions towards buying Mysore Silk Sarees. It examines the branding components and how it affects the consumers decisions. It studies the complex relationship of consumer preferences, brand influence, and the traditional realm of buying Mysore silk sarees and understanding the customer needs, that includes design, color, pattern, quality, trust, celebrity endorsement, brand name, tradition.

Place and Duration of Study: The study was conducted in Bangalore city, with also include people who might be the visitors to the city. Duration of the study was 2 months from May and June 2023.

Study Design: The research design used is Descriptive design. In this study design, features, behaviors, or occurrences are carefully observed and described without the usage of manipulative factors. It seeks to give readers a precise and thorough overview of the topic under study. This design gives a better understanding to the researchers into current patterns, linkages, and trends, so that it will give them a scope of further research opportunities. Data has been gathered by using both statistical methods and theme classification for qualitative inputs. When navigating the world of Mysore silk saree procurement, this analytical phase sought to identify trends, patterns, and recurring themes relating to the perceived advantages associated with brands.

Results: The research results provide brands, producers, and marketers with concrete ideas on how to incorporate the observed advantages into their branding strategy and strengthen consumer loyalty and trust. Mysore silk creates a brand image in the customer’s mindsets and maintains a long-term relationship with their customers.

Conclusion: Purchasing a Mysore Silk Saree is an act of supporting regional craftspeople, conserving history, and boosting local economies. Additionally, these sarees became symbols of distinction, denoting not just individual pride but also a group ties to a past that still permeates modern life.

 

Author (s) Details

Aishwarya S Arahunasi
Acharya Institute of Technology, India.

 

Juin Choudhury
Acharya Institute of Technology, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH25

A Survey on Investigating Machine Learning Approaches for Real-time Yoga Pose Rectification | Chapter 24 | Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

Yoga is an ancient technique, which is based on a science, which focuses on the harmony between mind and body. This practice is highly recommended by doctors for curing different health ailments, yet many struggle with proper execution of asana which may put the user at risk of injury. Hence, it brings the need to perform the asanas accurately. This paper delves into the various methods used to solve the difficulty of grasping yoga poses by precisely identifying and guiding practitioners in real-time and addresses these challenges by leveraging computer vision and machine learning (ML). The methodologies explored also include deep learning (DL), and hybrid models. Specifically, neural networks like CNNs and key point detection techniques, such as those implemented with OpenCV, OpenPose, and Mediapipe, significantly improve the accuracy of pose estimation. The integration of these technologies allows for real-time feedback, aiding practitioners in maintaining correct poses and reducing injury risks. Moreover, with a virtual yoga guide, users can practice yoga anytime also eliminating the hassle and expense of commuting to yoga centers and gyms. It helps the user maintain accurate yoga poses and avoid injuries which can hamper the body in the long term, making it easier to practice yoga at home. This makes wellness practices like yoga accessible and vision to have a huge contribution to a healthier society.

 

Author (s) Details

 

Mary M Dsouza
Department of ISE, Acharya Institute of Technology, Bangalore,560107, India.

 

Nidhi Charate
Department of ISE, Acharya Institute of Technology, Bangalore,560107, India.

 

Gauthami Shirodkar
Department of ISE, Acharya Institute of Technology, Bangalore,560107, India.

 

Adarsh Chetri
Department of ISE, Acharya Institute of Technology, Bangalore,560107, India.

 

Apoorva S
Department of ISE, Acharya Institute of Technology, Bangalore,560107, India.

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH24

Indonesian Politics Articles Hoax Determination on Social Media | Chapter 23| Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

Currently, a lot of news about politics can cause misinterpretation because the news is not necessarily true or a hoax. Hoax is fake news spread to gain trust so that people feel confident the content is true. Another impact of hoaxes can be detrimental to people's emotions and finances. In Indonesia, especially DKI Jakarta, the spread of hoaxes ahead of the general election, between September 2023 and February 2024, is very high. To filter articles on social media, it is necessary to classify political news whether it falls into the hoax or non-hoax category. The hoax classification process uses a preprocessing stage which consists of tokenization and winnowing. Followed by the process of weighting words and Jaccard similarities until the classification process using the N-Gram method can provide accuracy in determining hoax or non-hoax news on social media. The aim of this research is to build a system model that can find political news information. The system will systematically determine news into a predetermined hoax or non-hoax label or category. Using a sample of 200 articles obtained from online social media. The article used is in the form of text without images included. Articles are taken from online social media because a lot of information is spread through social media. The research will be made into two categories or labels, namely hoax and non-hoax. The evaluation results in this research use a confusion matrix, where the precision obtained is 0.90, the recall is 0.78 and the accuracy obtained is 85%. Using the Vector Space Model method and Jaccard stemming, and similarity can make it easier to classify large numbers of articles.

 

Author (s) Details

Wiwin Windihastuty
Universitas Budi Luhur, Jl. Ciledug Raya, Pesanggrahan, Jakarta Selatan, Indonesia.

 

Goenawan Brotosaputro
Universitas Budi Luhur, Jl. Ciledug Raya, Pesanggrahan, Jakarta Selatan, Indonesia.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH23

An Empirical Study on Millennial’s Behavior towards Perception of Investment Avenues with Reference to the Kutch Region of the Gujarat | Chapter 22 | Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

The finance sector is a vital component of the economy, serving as a stimulant for economic growth, resource allocation, and risk management. It contributes to the creation of capital by mobilizing savings and directing them towards investments. In this investment decision, the investors play a crucial role in the economic development. This study’s primary goal is to examine the effects of gender, occupation, income level, and annual savings on the investment decision. The author also aims to find out the impact of investment objectives on the investment decisions of millennials. Millennials represent a large and influential portion of the population. Their decisions make a huge difference in the economy and it is essential to find the factors that affect the millennial’s investment behaviour. The study fills a deliberate gap by identifying the influence of demographics on the financial choices of millennials. In this study, the researcher has studied the investment behaviour of the 102 working millennials in the Kutch region of Gujarat. The study focuses on millennials' objectives while choosing the investment avenues, and factors influencing investment decisions. The analysis and data interpretation was done by SPSS. The research emphasizes that something is lacking in the study and found the absence of a strong correlation between annual savings and monthly income. The gender is significantly associated with gold & silver and Real estate. As the same demographic factor occupation is also significantly associated with the traditional avenues.

 

Author (s) Details

 

Hardika Rajubhai Jadav
School of Doctoral Research and Innovation, GLS University, India.

 

Dharmesh Shah
Faculty of Management, GLS University, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH22

Fostering Employee Relations through Communication Practices: Creating a Culture of Trust, Sharing and Transparency | Chapter 21 | Leading the Charge: A Guide to Management, Entrepreneurship and Technology in the Dynamic Business Landscape Edition 1

Aims: The purpose of this study is to ascertain how the Dhanturi Group of Hotels Pvt Ltd's employee relationships are affected by good communication skills.

Study Design: A descriptive study was conducted among randomly selected respondents.

Place and Duration of Study: The research took place within Dhanturi Group of Hotels Pvt Ltd.

Methodology: The study included 125 individuals, aged between 20 and 35, 80 of whom were men and 45 of whom were women. investigated how communication behaviors affect employee relationships using a descriptive research methodology. Surveys, interviews, and focus groups were conducted with a representative sample of 125 workers from a variety of departments to gauge opinions about communication methods and levels of trust. While the goal of qualitative analysis was to find important themes in employee experiences, survey data analysis attempted to identify trends.

Results: There are statistically significant positive associations between employee relationships and sharing, transparency, and trust, according to an analysis of correlations among key factors related to positive employee relationships through effective communication. The Pearson correlation coefficients for these relationships ranged from 0.117 to 0.294. An R-value of 0.860, which suggests that these communication behaviors account for 74% of the variance in employee relationships, and an Adjusted R Square value of 0.733, which indicates a good model fit, validated the strong positive relationship between the independent variables (sharing, transparency, and trust) and the dependent variable (employee relationships).

Conclusion: The study emphasizes how crucial it is to promote openness, confidence, and a sharing culture in communication methods in order to improve healthy employee connections. Transparency was found to be the strongest predictor, followed by trust, and sharing, and these findings provide insightful information for organizations looking to create focused strategies to foster a collaborative and supportive work environment. These findings also suggest possible areas for future research into interaction effects and contextual factors.

 

Author (s) Details

 

Monica. M
Acharya Institute of Technology, Bengaluru, India.

 

Suhas Patel
Acharya Institute of Technology, Bengaluru, India.

 

G. Ramanaiah
Presidency University, Presidency School of Management, Bengaluru, India.

 

Channakeshava H C
BMSIT, Bengaluru, India.

 

Bhavya V M
Acharya Institute of Technology, Bengaluru, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mono/978-93-48859-98-3/CH21

Applications of Green Chemistry and Nanotechnology as a Potential Solution for Sustainability | Chapter 8 | Recent Developments in Chemistry and Biochemistry Research Vol. 10

Nanotechnology is a crucial tool for the environmentally friendly synthesis of noble nanomaterials. Green synthesis is superior to traditional chemical processes due to its cost-effectiveness, reduced pollution, and enhanced environmental and public health benefits. Nanomaterials, derived from plants, offer numerous benefits to living things. Additionally, nanomaterials are cost-effective, and have minimal environmental and health impacts, making them a promising area of nanotechnologies. This study explores the integration of green chemistry and nanotechnology as a potential solution for sustainable development in the context of global environmental awareness. This study also discusses the integration of various domains and the potential of innovative nanomaterials and methodologies to enhance green chemistry principles. Utilizing nanotechnology can lead to the formation of more cost-effective, environmentally friendly, and sustainable chemical processes. This research shows recent advancements in green synthesis techniques, nanocatalysis, and the utilization of nanomaterials for energy storage and environmental remediation. It emphasizes balancing sustainability by considering nanotechnology's potential risks and lifetime implications. The study explores the green synthesis of nanomaterials, highlighting their benefits in reducing harmful compounds, energy consumption, and process effectiveness. It highlights nanostructured materials for renewable energy, environmental monitoring sensors, and cleaner chemical reactions. It emphasizes the need for risk evaluations and lifecycle analysis for responsible innovation and sustainable practices. This study's findings highlight the necessity of comprehensive regulatory bases and ongoing interdisciplinary research to optimize emerging technologies' economic and environmental benefits. Integrating nanotechnology and green chemistry is crucial to a more sustainable future. This review explores the eco-friendly synthesis of plant-based nanoparticles and their applications in catalysis, drug development, diagnostics, and biological research.

 

 

Author (s) Details

 

Selvaraja Elumalai
Raffles University, Neermanda, India.

 

Meenakshi Sharma
Raffles University, Neermanda, India.

 

Venkata Lakshamana Sagar Dantinapalli
Raffles University, Neermanda, India.

 

Mylsamy Palanisamy
Acharya Nagarjuna University, India.

 

Akhilesh Kumar Kuril
Bhagwant University, Sikar Road, Ajmer, Rajasthan, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v10/3857

Carbodome: Linking Carbon Distribution to Protein Stability and Function | Chapter 5 | Recent Developments in Chemistry and Biochemistry Research Vol. 10

A novel metric Carbodome quantifies the carbon content of amino acid residues, offering insights into their hydrophobic or hydrophilic tendencies and their profound effects on protein stability and function. This study highlights key findings, demonstrating that amino acids with higher Carbodome values, such as tryptophan and phenylalanine, contribute to hydrophobic core stability, while lower Carbodome residues like arginine enhance solubility and surface interactions. The implications of carbon distribution extend to protein folding dynamics, structural integrity, and interactions, providing a foundation for advances in protein engineering, therapeutic design, and disease understanding. These findings underscore the pivotal role of carbon in shaping protein structure and functionality.

 

Author (s) Details

Rajasekaran Ekambaram
V.S.B. Engineering College, Karur-639111, TN, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v10/3791

Impact of Zn2+ and Selenite on Rat Ascites Hepatoma AS-30D Cells and Rat Liver Mitochondria: A Comparison with Cd2+, Hg2+, Cu2+, and Ca2+ | Chapter 7 | Recent Developments in Chemistry and Biochemistry Research Vol. 10

The objective of this work was to study the molecular mechanisms of metal/metalloid cytotoxicity using Zn²⁺ and sodium selenite (Na2SeO3) and compare them at the cellular and mitochondrial levels. For this, we used rat ascites hepatoma AS-30D cells and rat liver mitochondria, as well as flow cytometry, spectrofluorometry, polarography and ion-selective electrode technique. Mitochondria of AS-30D cells were found to be a major target for both Zn²⁺ and selenite. High [mu]M concentrations of Zn²⁺ or selenite were highly cytotoxic and killed these cells by both apoptotic and necrotic pathways. Both Zn²⁺ and selenite induced significant changes in the intracellular generation of reactive oxygen species (ROS) and caused mitochondrial dysfunction through disturbance of the mitochondrial electron transport chain (mtETC), dissipation of mitochondrial membrane potential, and opening of mitochondrial permeability transition pores. Significant differences were revealed in the toxic effects of Zn²⁺ and selenite on both AS-30D cells and isolated rat liver mitochondria. In particular, selenite caused a significantly higher level of intracellular ROS production (an early cellular event) compared to Zn²⁺, but a lesser membrane potential loss and a smaller decrease in the rate of maximal (fully uncoupled) cellular respiration, while mtETC disturbance was a early and key event in the mechanism of Zn²⁺ cytotoxicity. Importantly, the data found on cells were in good agreement with those obtained on isolated mitochondria. In addition, the sequence of events manifested in the mitochondrial dysfunction induced by the tested metal/metalloid was compared with that for Cd²⁺, Hg²⁺, Cu²⁺, and Ca²⁺ + on the same model system. As a consequence, the molecular mechanisms of the metal/metalloid toxicity have been elucidated, highlighting differences in their action on mitochondrial function and cell fate and providing a rationale for the combined use of such compounds in various therapeutic strategies, including anticancer and many others.

 

Author (s) Details

 

Elena A. Belyaeva
Laboratory of Comparative Biochemistry of Inorganic Ions, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Thorez Pr. 44, 194223, St.-Petersburg, Russia.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v10/3599

Benzisoxazole Derivatives: Synthesis and Their Therapeutic Significance in Medicinal Chemistry | Chapter 6 | Recent Developments in Chemistry and Biochemistry Research Vol. 10

Benzisoxazoles and their derivatives have been extensively investigated and applied across various medical fields. These compounds have demonstrated significant therapeutic potential in the management of cardiovascular conditions, including myocardial infarction, hypertension, and hyperlipidemia. Additionally, they have been utilized in the treatment of inflammatory diseases, irritable disorders, and gastrointestinal conditions such as peptic ulcers. Benzisoxazoles also show promise in addressing metabolic disorders, including obesity, diabetes, and metabolic syndrome. Moreover, novel benzisoxazole derivatives exhibit a range of bioactive properties, including anti-inflammatory, anti-cancer, anti-glycation, and antibacterial activities. The continuous advancement in the development of highly active benzisoxazole-based compounds underscores their potential as scaffolds for future therapeutic candidates. This chapter focuses on the synthesis of benzisoxazole derivatives using various methodologies and highlights the significance of this pharmacophore in medicinal chemistry.

 

Author (s) Details

 

Mahima Samanth
Department of Chemistry, Vijaya Vittala Institute of Technology, Bengaluru-560 077, Karnataka, India.

 

Mahesh Bhat
Department of Chemistry, Poornaprajna College (Autonomous), Udupi-576 101, Karnataka, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v10/3809

Functionalization of Natural Compounds to Enhance the Bioactivity of Zerumbone in Cancer Chemotherapy | Chapter 4 | Recent Developments in Chemistry and Biochemistry Research Vol. 10

The alkylation reaction was employed to conjugate zerumbone with 3-substituted quinazolinone-4(3H)-ones and quinolines, resulting in the synthesis of 11 novel conjugates. These conjugates were thoroughly characterized using 1D-, 2D-NMR, and HRMS spectral data. Their enhanced bioactivity was evaluated through anti-inflammatory assays, specifically by inhibiting NO production in RAW 267.4 cells. Additionally, their cytotoxic activity was assessed against three human cancer cell lines: HepG2, SK-LU-1, and MCF-7. The results demonstrated that all 11 conjugates exhibited significantly potent cytotoxic activity, with IC50 values ranging from 1.01 to 9.86 µg/mL, surpassing the efficacy of the parent compound zerumbone. Furthermore, in silico studies, including EGFR inhibitory activity through docking and molecular dynamics simulations, were conducted to identify the most potent compounds. These studies highlighted the key interactions of zerumbone derivatives 16a-k with critical amino acids in the active site of the EGFR (PDB ID 4HJO) protein.

 

Author (s) Details

Ngoc Hung Truong
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 1H Building, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi, 100000, Vietnam.

 

Duc Anh Le
Institute of Chemistry and Material, Academy of Military Science and Technology, 17 Hoang Sam Street, Cau Giay, Hanoi, 100000, Vietnam.

 

Thi Ha Vu
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 1H Building, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi, 100000, Vietnam.

 

Thi Inh Cam
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 1H Building, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi, 100000, Vietnam.

 

Huu Nghi Do
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 1H Building, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi, 100000, Vietnam.

 

Manh Cuong Nguyen
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 1H Building, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi, 100000, Vietnam.

 

Khac Vu Tran
Hanoi University of Science and Technology, 1 Dai Co Viet Str., Hai Ba Trung Street, Hanoi 100000, Vietnam.

 

Hanh Nguyen Tran
University of Science and Technology of Hanoi, A21 Building, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi 100000, Vietnam.

 

Van Chung Pham
Applied Medicinal Chemistry and Pharmaceutical Technology JSC, 45/24 Dien Bien Phu Street, Ngo Quyen, Hai Phong 180000, Vietnam.

 

Van Chinh Luu
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 1H Building, 18 Hoang Quoc Viet Street, Cau Giay, Hanoi, 100000, Vietnam.

 

Please see the book here:- https://doi.org/10.9734/bpi/rdcbr/v10/3608