Association between Metabolic Risk Factors and Severity of Knee Osteoarthritis in Type 2 Diabetes Mellitus Patients | Chapter 4 | Current Progress in Medicine and Medical Research Vol. 2

 This unit aimed to explore whether individuals pain from more severe body part osteoarthritis display a worse metabolic profile. Osteoarthritis (OA) is individual of the most low disabling afflictions and has become a growing health management problem by way of its increasing predominance worldwide. A greater prevalence of OA has been stated among cases with metabolic condition, and diabetes mellitus (DM) was reported as an independent prophet for OA. This cross-sectional study was administered in 2018 and included 57 patients accompanying type-2 diabetes mellitus (T2DM). Both demographic facts and results from metabolic tests were gathered. Anteroposterior (AP) and sideways radiographs of both knees were taken later a medical history was captured and a physical examination was performed. The asperity of OA was then detached into two groups using the Kellgren-Lawrence (KL) categorization method.  A total of 57 patients accompanying T2DM enrolled in the study, of that 32 patients exhibited grade 1 or 2 KL (group A) and 25 accompanying grade 3 or 4 KL (group B). The mean age and mean body bulk index (BMI) were higher in group B distinguished to group A, and the differences were statistically meaningful (P-value = 0.01). skilled is a vicious cycle between being corpulent/obese and bearing a more severe form of OA, which wealth that people accompanying more severe OA undertake less physical activity due to pain and discomfort, chief to weight gain. On the other hand, corpulence increases mechanical forces across weight-posture joints. As accompanying the other metabolic tests, the mean antitoxin hemoglobin A1C (HbA1c) level was not statistically significant (P-worth = 0.34). The data told that metabolic factors play a minor role in the asperity of OA in patients accompanying DM, and these changes are more influenced by increasing BMI and age.

Author(s) Details:

Mahmoud Reza Rahimi Barghani,

Endocrinology Department, Isfahan University of Medical Sciences, Isfahan, Iran.

Noushin Khalili,

Endocrinology Department, Isfahan University of Medical Sciences, Isfahan, Iran.

Mansour Salesi,

Rheumatology Department, Isfahan University of Medical Sciences, Isfahan, Iran.

Azin Shayganfar,

Radiology Department, Isfahan University of Medical Sciences, Isfahan, Iran.

Sarvenaz Rahimibarghani,

Physical Medicine and Rehabilitation Department, Tehran University of Medical Sciences, Tehran, Iran.

Please see the link here: https://stm.bookpi.org/CPMMR-V2/article/view/11283