Optimization of Stach Phthalate as a Novel Superdisintegrant in the Formulation of Acyclovir Fast Dissolving Tablets | Chapter 2 | Novel Aspects on Pharmaceutical Research Vol. 6

 Fast disintegrating tablets are alternative to conventional portion of drug or other consumable forms for patients like geriatrics, pediatrics, and disabled patients, the one experience difficulty in taking into throat of conventional portion of drug or other consumable forms. The current studies objective is to cultivate and improve acyclovir tablets that dissolve fast using a new superdisintegrant starch phthalate. Antiviral medication acyclovir has a reduced bioavailability (15–30%) because it dissolves poorly in water. Our present research aim is to make acyclovir fast-disappearing tablets with the novel superdisintegrant vigor phthalate and other famous superdisintegrants like croscarmellose sodium and crospovidone in order to increase the bioavailability of acyclovir. The formulation of tablets understood a 23 factorial  design. Esterification has been used to devise starch phthalate. There has been physico-synthetic characterisation of the starch phthalate. Acyclovir is the preferred medicine, and tests are finished using FTIR (Fourier-transform shade resembling such a color spectroscopy), TLC (Thin layer chromatography), and DSC (Differential flipping through studies) to see if there is some interaction. All pellet formulations passed the tests for severity, friability, drug content, wetting time, and artificial drug dissolution. It was driven that each formulation's tablet join pharmacopoeial standards and was of excellence. The study came to the decision that starch phthalate improved the drug's strength to dissolve when linked with croscarmellose and crospovidone. Thus, a novel superdisintegrant called vigor phthalate can be working to create tablets that dissolve urgently.

Author(s) Details:

R. Santosh Kumar,
GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, India.

Annu Kumari,
GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, India.

T. Mallika,
SrinivasaRao College of Pharmacy, P.M.Palem, Visakhapatnam-41, A.P, India.

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