Formulation Evaluation of Acyclovir Orally Disintegrating Tablets: A Brief Overview | Chapter 4 | Advanced Concepts in Pharmaceutical Research Vol. 6

The present study highlights about formulation development and evaluation of acyclovir orally disintegrating tablets. A vast variety of pharmaceutical research is directed at developing new dosage forms for oral administration. Most of these efforts have focused on either formulating novel drug delivery systems or increasing the patient compliance. Because oral disintegrating systems have the highest patient compliance, particularly in pediatric and geriatric populations, they offer an advantage over oral drug delivery systems. Furthermore, because they are unable to swallow significant amounts of water, patients with dysphagia, motion sickness, recurrent emesis, and mental illnesses prefer these drugs. Further, drugs exhibiting satisfactory absorption from the oral mucosa or intended for immediate pharmacological action can be advantageously formulated in these dosage forms. However, the requirements of formulating these dosage forms with mechanical strength sufficient to withstand the rigors of handling and capable of disintegrating within a few seconds on contact with saliva are inextricable. Therefore, research in developing orally disintegrating systems has been aimed at investigating different excipients as well as techniques to meet these challenges. Acyclovir is an antiviral drug used for the treatment of herpes simplex virus (HSV), mainly HSV-1 and HSV-2 and varicella zoster virus. It is a BCS class III drug. Hence an orally disintegrating tablet formulation of acyclovir was prepared by direct compression and wet granulation after incorporating super disintegrants croscarmellose sodium and sodium starch glycolate. Seven formulations were prepared. Tablet containing sodium starch glycolate showed excellent in vitro dispersion time and drug release as compared to other formulation. After study of seven formulations DT3 showed short dispersion time with maximum drug release in 10 min. It is concluded that fast disintegrating acyclovir tablets could be prepared by direct compression using super disintegrants. It can be concluded that formulation of dispersible tablet using sodium starch glycolate as a super disintegrants showed improved solubility and hence better disintegration.

Author(s) Details:

Manisha Karpe,
Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Navi Mumbai 400 614, Maharashtra, India.

Nikhil Mali,
Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Navi Mumbai 400 614, Maharashtra, India.

Vilasrao Kadam,
Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Navi Mumbai 400 614, Maharashtra, India.

Please see the link here: https://stm.bookpi.org/ACPR-V6/article/view/13414

Optimization of Stach Phthalate as a Novel Superdisintegrant in the Formulation of Acyclovir Fast Dissolving Tablets | Chapter 2 | Novel Aspects on Pharmaceutical Research Vol. 6

 Fast disintegrating tablets are alternative to conventional portion of drug or other consumable forms for patients like geriatrics, pediatrics, and disabled patients, the one experience difficulty in taking into throat of conventional portion of drug or other consumable forms. The current studies objective is to cultivate and improve acyclovir tablets that dissolve fast using a new superdisintegrant starch phthalate. Antiviral medication acyclovir has a reduced bioavailability (15–30%) because it dissolves poorly in water. Our present research aim is to make acyclovir fast-disappearing tablets with the novel superdisintegrant vigor phthalate and other famous superdisintegrants like croscarmellose sodium and crospovidone in order to increase the bioavailability of acyclovir. The formulation of tablets understood a 23 factorial  design. Esterification has been used to devise starch phthalate. There has been physico-synthetic characterisation of the starch phthalate. Acyclovir is the preferred medicine, and tests are finished using FTIR (Fourier-transform shade resembling such a color spectroscopy), TLC (Thin layer chromatography), and DSC (Differential flipping through studies) to see if there is some interaction. All pellet formulations passed the tests for severity, friability, drug content, wetting time, and artificial drug dissolution. It was driven that each formulation's tablet join pharmacopoeial standards and was of excellence. The study came to the decision that starch phthalate improved the drug's strength to dissolve when linked with croscarmellose and crospovidone. Thus, a novel superdisintegrant called vigor phthalate can be working to create tablets that dissolve urgently.

Author(s) Details:

R. Santosh Kumar,
GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, India.

Annu Kumari,
GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, A.P 530045, India.

T. Mallika,
SrinivasaRao College of Pharmacy, P.M.Palem, Visakhapatnam-41, A.P, India.

Please see the link here: https://stm.bookpi.org/NAPR-V6/article/view/11356