The present study highlights about formulation development
and evaluation of acyclovir orally disintegrating tablets. A vast variety of
pharmaceutical research is directed at developing new dosage forms for oral
administration. Most of these efforts have focused on either formulating novel
drug delivery systems or increasing the patient compliance. Because oral
disintegrating systems have the highest patient compliance, particularly in
pediatric and geriatric populations, they offer an advantage over oral drug
delivery systems. Furthermore, because they are unable to swallow significant
amounts of water, patients with dysphagia, motion sickness, recurrent emesis,
and mental illnesses prefer these drugs. Further, drugs exhibiting satisfactory
absorption from the oral mucosa or intended for immediate pharmacological
action can be advantageously formulated in these dosage forms. However, the
requirements of formulating these dosage forms with mechanical strength
sufficient to withstand the rigors of handling and capable of disintegrating
within a few seconds on contact with saliva are inextricable. Therefore,
research in developing orally disintegrating systems has been aimed at
investigating different excipients as well as techniques to meet these
challenges. Acyclovir is an antiviral drug used for the treatment of herpes
simplex virus (HSV), mainly HSV-1 and HSV-2 and varicella zoster virus. It is a
BCS class III drug. Hence an orally disintegrating tablet formulation of
acyclovir was prepared by direct compression and wet granulation after
incorporating super disintegrants croscarmellose sodium and sodium starch
glycolate. Seven formulations were prepared. Tablet containing sodium starch
glycolate showed excellent in vitro dispersion time and drug release as compared
to other formulation. After study of seven formulations DT3 showed short
dispersion time with maximum drug release in 10 min. It is concluded that fast
disintegrating acyclovir tablets could be prepared by direct compression using
super disintegrants. It can be concluded that formulation of dispersible tablet
using sodium starch glycolate as a super disintegrants showed improved
solubility and hence better disintegration.
Author(s) Details:
Manisha Karpe,
Department of Pharmaceutics, Bharati Vidyapeeth’s College of
Pharmacy, CBD Belapur, Navi Mumbai 400 614, Maharashtra, India.
Nikhil
Mali,
Department
of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Navi
Mumbai 400 614, Maharashtra, India.
Vilasrao Kadam,
Department of Pharmaceutics, Bharati Vidyapeeth’s College of
Pharmacy, CBD Belapur, Navi Mumbai 400 614, Maharashtra, India.
Please see the link here: https://stm.bookpi.org/ACPR-V6/article/view/13414
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