Introduction: Zinc, a crucial trace element in the human
body, plays a pivotal role in various physiological processes due to its
involvement in enzyme structure and function. Its significance in health and
disease, particularly in liver disorders and cancer, has gained attention.
However, inconsistencies exist in literature regarding zinc levels and their
association with hepatic carcinomas.
Methods: A meta-analysis was conducted following PRISMA guidelines to analyze
the relationship between serum zinc levels and hepatic cancer. Data were
extracted from epidemiological studies retrieved from NLM-PubMed databases.
Inclusion criteria involved studies assessing blood zinc levels' association
with liver cancer and providing mean values with standard deviation.
Results: Seven eligible studies were included, showing significant
heterogeneity. The combined average zinc level in hepatic carcinoma patients
was 74.06 µg/dL (95% CI: 61.0 - 87.06), indicating a substantial deviation from
normal levels. Publication bias was observed.
Conclusion: The meta-analysis underscores the importance of zinc in liver cancer
risk assessment and disease progression. Lower than expected pooled zinc levels
in hepatic carcinoma patients highlight its potential as a predictive marker
for liver malignancies and chronic liver diseases. Further research is
warranted to elucidate zinc's precise role and clinical implications in hepatic
carcinogenesis.
Author(s) Details:
Abhishek Bansal,
Department of Biochemistry, Pt. B D Sharma PGIMS, Rohtak, HR, India.
Praveen
Prashant,
Department
of Biochemistry, Pt. B D Sharma PGIMS, Rohtak, HR, India.
Pragya Dixit,
ESI Health Care Haryana, ESI Hospital Panipat, HR, India.
Sonia Vashist,
Department of Dermatology, Tripti Hospital, Rohak, HR, India.
Please see the link here: https://stm.bookpi.org/NVMMS-V1/article/view/13655
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