The present study highlights about Fungal Glycosidases in
Sporothrix Species and Candida albicans. Through the hydrolysis of glycosidic
bonds in glycosides, enzymes known as glycoside hydrolases (GHs) take part in a
variety of biological activities in fungi and other organisms. They are
substantial topics of research in molecular biology and biochemistry and have
essential functions in the breakdown of carbohydrates and the building of
glycoproteins. Based on amino acid sequence similarities and 3-dimensional
structures in the carbohydrate-active enzyme (CAZy), they have been classified
in 171 families. Members of some of these families also exhibit the activity of
trans-glycosydase or glycosyl transferase (GT), i.e., they create a new
glycosidic bond in a substrate instead of breaking it. Fungal glycosidases are
important for virulence by aiding tissue adhesion and colonization, nutrition,
immune evasion, biofilm formation, toxin release, and antibiotic resistance.
Here, we review fungal glycosidases with a particular emphasis on Sporothrix
species and C. albicans, two well-recognized human pathogens. Covered issues
include a brief account of Sporothrix, sporotrichosis, the different types of
glycosidases, their substrates, and mechanism of action, recent advances in
their identification and characterization, their potential biotechnological
applications, and the limitations and challenges of their study given the
rather poor available information. The study approaches will strengthen genetic
glycoengineering, as glycosylation/deglycosylation can be used to modulate the
efficiency of protein pharmaceuticals, the modification of glycoprotein
antibodies by adding or changing the position of some sugars, changing the
properties of recombinant proteins, etc. These achievements will impact the
areas of biotechnology, biomedicine, and consequently, human health.
Author(s) Details:
Jorge A. Ortiz-Ramírez,
Departamento de Biología, División de Ciencias Naturales y Exactas,
Universidad de Guanajuato, Guanajuato 36050, Mexico.
Mayra
Cuéllar-Cruz,
Departamento
de Biología, División de Ciencias Naturales y Exactas, Universidad de
Guanajuato, Guanajuato 36050, Mexico.
Julio C. Villagómez-Castro,
Departamento de Biología, División de Ciencias Naturales y Exactas,
Universidad de Guanajuato, Guanajuato 36050, Mexico.
Everardo López-Romero,
Departamento de Biología, División de Ciencias Naturales y Exactas,
Universidad de Guanajuato, Guanajuato 36050, Mexico.
Please see the link here: https://stm.bookpi.org/RPMAB-V1/article/view/13853
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