The objective of this book chapter is to report the outcome
of investigating the mechanism of effect of consuming plantain diet on fear and
anxiety behavior, using mice in experiment model. Two categories (cat) of three
groups of mice were administered as follows; cat 1 - normal chow (group
A/control), 50% plantain (group B), 100% plantain (group C) and cat 2 - normal
chow (group 1), 100% plantain (group 2), 100% plantain + serotonin antagonist
–ritanserin (group 3) respectively for a period of 30 days. Thereafter, both
categories of mice were subjected to neurobehavioral studies using elevated
plus maze and light/dark box, after which they were sacrificed and portion of
brain tissue were collected and homogenized for estimation of serotonin (5-HT)
concentration using High performance liquid chromatography (HPLC). Variability
among the groups was determined by analysis of variance (ANOVA), whereas
between groups, appropriate comparisons were made by Student t-test. Result of
neurobehavioral analysis showed a significant increase in open arm duration and
time spent in light chamber for plantain-fed mice than control; implying that
plantain reduced anxiety and fear behavior for cat 1. The neurochemical analysis for cat 1 showed
that 5-HT level was significantly (p<0.001) elevated in the brain of
plantain-diet fed mice than control (group A), indicating that plantain
increased 5-HT concentration. In the cat 2, duration in open arm and in light
camber was reduced significantly p<0.05 in group 3 (100% plantain +
ritanserin) than control and 100% plantain group; implying increased fear and
anxiety behavior. These results suggest that plantain meal may have influenced
emotion by reducing fear and anxiety, with 5-HT as an active ingredient in
plantain.
Author(s) Details:
Peter P. Erigbali,
Department of Human Physiology, Faculty of Basic Medical Sciences,
Niger Delta University, Wilberforce Island, Nigeria.
Oweipikumo F.
Dabirilagha,
Department
of Human Physiology, Faculty of Basic Medical Sciences, Niger Delta University,
Wilberforce Island, Nigeria.
Price P. Joffa,
Department of Human Physiology, Faculty of Basic Medical Sciences,
Niger Delta University, Wilberforce Island, Nigeria.
Eme E. Osim,
Department of Human Physiology, Faculty of Basic Medical Sciences,
University of Calabar, Nigeria.
Please see the link here: https://stm.bookpi.org/NVMMS-V1/article/view/13661
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