Optimisation of Starch Glutamate as a New Modified Superdidintegrant in the Formulation of Ibuprofen Fast Dissolving Tablets | Chapter 3 | Novel Aspects on Pharmaceutical Research Vol. 6

 The episode highlights about augmentation of the solubility and bioavaialibility of the ibuprofen by formulating it into fast dissolving tablets engaging starch gutamate as a novel superdisintegrant. The idea of Fast Dissolving Drug Delivery Systems (FDDS) emerged from the desire to determine patient with common means of taking their drug. FDDS gaining recognition nowadays on account of its enhanced patient compliance in pediatrics and geriatric victims who knowledge difficulties in taking into throat. The esterification technique was used to design starch glutamate from native potato vigor and glutamic acid. Ibuprofen fast-dissolving tablets were established using the direct condensation method and a difference of superdisintegrants, including starch glutamate (a novel superdisintegrant). The processed ibuprofen fast dissolvng tablets were evaluated for differing pre & post compression limits along with the in-vitro and in-vivo release characterisitics. Optimized expression stability studies were performed at increased conditions for 6 months as per ICH & WHO directions. Fast dissolving tablets of ibuprofen were planned by employing vigor glutamate as a superdisintegrant showed good tablet features and showed an raised dissolution adeptness of the drug. Hardness of the fast dissolving tablets of ibuprofen was found expected in between 3.7 ± 0.02 to 3.9 ± 0.02 Kg/cm2. Among all the formulations (F1 to F8), the expression F4 which hold 5% starch glutamate and 5% croscarmellose sodium as superdisintegrants demonstrated 99.7±0.34% drug dissolution within 5 summary. From the results of the tablet judgment tests, it was known that all the ibuprofen fast discontinuing tablet formulations passing the official pharmacopoeial dose evaluation tests. Pharmacokinetic parameters of the improved ibuprofen fast dissolving capsule formulation F2 , achieved peak plasma aggregation in a short period of time and showed raised in an absorption rate accompanying an increased relative bioavailability of the drug. Optimised expression peak plasma aggregation In accordance with ICH stability requirements, F2 was fast attained, raised relative bioavailability, and was discovered expected stable all the while accelerated stability experiment. Starch glutamate can be secondhand as a superdisintegrant in the formulation of fast-annulling tablets to increase the solubility and bioavailability of the poorly soluble drugs, in accordance with studies on drug-excipient compatibility, disintegration occasion, in-vitro dissolution, and pharmacokinetics.

Author(s) Details:

R. Santosh Kumar,
GITAM School of Pharmacy, GITAM (Deemed to be university), Rushikonda, Visakhapatnam, A.P 530045, India.

Sahithi Mudili,
GITAM School of Pharmacy, GITAM (Deemed to be university), Rushikonda, Visakhapatnam, A.P 530045, India.

Please see the link here: https://stm.bookpi.org/NAPR-V6/article/view/11357