Applicability of a New Modified Calcium Starch as Release Retarding Polymer: A Comparative Study | Chapter 10 | Novel Aspects on Pharmaceutical Research Vol. 6

 This phase evaluate the drug release retarding effectiveness of a newly modified vigor named calcium vigor, in comparison to famous polymers namely hydroxy propyl methyl hydrogen (HPMC), sodium carboxy methyl cellulose (sodium CMC), ethyl cellulose and olibanum paste. Controlled-release dosage forms have created significant progress in conditions of clinical efficacy and patient agreement. Drug release from the systems bear be at a asked rate, predictable and reproducible. Polymers, that are used as release retarding materials in the design of regulated-release dosage forms play a lively role in ruling the delivery of drug from these portion of drug or other consumable forms. Gliclazide (30 mg) matrix tablets were created utilizing calcium starch and the added polymers at a polymer content of 5%, and the tablets underwent experiment. All of the calcium starch- and other polymer-located matrix tablets moderately released gliclazide over a ending of 12 to 24 hours. The release mechanism each of the prepared matrix tablets was erect to follow non-fickian spread. The release of Gliclazide from the matrix tablets steal hydroxy propyl methyl cellulose, ethyl cellulose, sodium CMC, and olibanum wax was relatively smart, and it was finished in 12hrs. But forge tablets prepared accompanying calcium starch, gliclazide release was slow and spread over 24 hours. The drug release was comparatively rapid in the case of sodium CMC, olibanum wax, ethyl cellulose and HPMC (98%- 99%) and the release was achieved within 8 – 12 hours with these tablets. In contrast, calcium vigor caused the gliclazide release expected gradual and out of touch with reality over 24 hours.

Author(s) Details:

Sailaja Gunnam,
Gokaraju Rangaraju College of Pharmacy, Affiliated with Osmania University, Hyderabad – 500090, India.

Monika Nijhawan,
Gokaraju Rangaraju College of Pharmacy, Affiliated with Osmania University, Hyderabad – 500090, India.

Rajeswari Aleti,
Gokaraju Rangaraju College of Pharmacy, Affiliated with Osmania University, Hyderabad – 500090, India.

Please see the link here: https://stm.bookpi.org/NAPR-V6/article/view/11364