Gold Nanoparticles as Theranostic Delivery System in Combating Various Diseases | Chapter 8 | Research Advances in Microbiology and Biotechnology Vol. 6

 This phase is mainly focused on golden nanoparticles (AuNPs), along with their mechanism of conduct, bio-distribution, pharmacokinetics, toxicities, host-invulnerable response, and their potential bio-healing applications against a lot of ailments. Due to the increase in diseases brought on by contamination and infectious microorganisms, it is needed to devise a theranostic delivery order based on targeted nanotechnology to treat particular aches. Conventional anti-microbial, anti-malignant, anti-atherosclerotic, and anti-endocarditic healings have been used to treat a variety of ailments, but these therapies have been connected to the development of multi-drug resistance (MDR), important toxic side effects, lacking therapeutic indices, and restricted drug bioavailability. In this concern, site-specific theranostic childbirth may be an important field of research to enhance drug-efficacy and decrease adverse side effects to host containers, while anti-microbial, anti-malignant, anti-atherosclerotic and antagonistic-endocarditic nanosized gold materials have arose as potent diagnostic and healing delivery system against miscellaneous diseases due to their singular size, shape and surface -dependent physico-synthetic, optical, photo-warm, photodynamic, radio-sensitizing and surface plasmon resonance features, ease of surface modification and high surface-to-capacity ratio -associated alive functional groups, bio-rapport, facile synthesis, and fixed nature. AuNPs, as nanotheranostics, may be used for a synergy of diagnostics and cure, owing to their ocular and surface plasmon resonance characteristics, ease of combination, controllable size and shape, colloidal support and tunable surface chemistry for achieving combination with biological moieties, followed by cargos-delivery, photo-depict and photo-thermal cure. The chapter also survey on the development of non-toxic and non-immunogenic AuNPs-covered cargos and ligands such as chitosan, polyethylene glycol (PEG) / polyethylene imine (PEI) with / outside sugars, peptides, proteins, antibodies and genes as theranostic delivery carrier in addition to system for targeting narrow molecules and theranostics to diseased sites through their ease of infiltration, accumulation and release.

Author(s) Details:

Ardhendu Kumar Mandal,
Central Instrumentation Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.

Please see the link here: https://stm.bookpi.org/RAMB-V6/article/view/11203