Dietary Natural Flavonoid Kaempferitrin Treats Colorectal Cancer by Targeting on the PI3K/AKT Signaling Pathway | Chapter 5 | Current Innovations in Disease and Health Research Vol. 3

 Colorectal tumor is the third most prevalent malignancy of all cancer types general, with an expected 2.4 lakhs occurrence by 2035. Flavonoids are a wide variety of polyphenols mainly found to have showed nutritional benefits. Kaempferitrin (Kaempferol-3,7-di-O-alpha-L-rhamnoside) is a glycosyloxyflavone that is kaempferol coupled to α-rhamnopyranosyl residues betwixt positions 3 and 7 respectively via glycosidic linkages. The microscopic formula C27H30O14 and has a molecular pressure of kaempferitrin 578.52 g/mol. Kaempferitrin a natural flavonoid has existed extracted from many edible plants that have stated anti-oxidant, anti-instigative, anti-diabetic, antagonistic-convulsant activities. Apoptosis induction, ROS result, and colorectal cancer (HT-29) container viability can all be inhibited by kaempferitrin in a aggregation-dependent manner. Additionally stimulating caspase-3 and increasing the percentages of cleaved PARP protein expression in HT-29 cells, kaempferitrin inferred caspase-dependent apoptosis. These kaempferitrin mediated apoptosis too exhibit a positive equivalence with the PI3/AKT pathway, suggesting that the HT-29 tumor cells may be point or direct at a goal downstream. Recent research has connected the PI3K/AKT pathway to the development of tumors and controls container death, distinction, and proliferation. Many malignancies, including colorectal malignancy, had a significant activation of the protein kinase B (PI3K/AKT) indicating pathway. Inhibiting the PI3K/AKT pathways again results in mitochondrial dysfunction, which produces ROS and kills cancer containers.

Author(s) Details:

Manju Vaiyapuri,
Department of Biochemistry, Periyar University, Salem – 636 011, India.

Lavanya Prathap,
Department of Anatomy, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai – 600077, India.

Mydhili Govindarasu ,
Department of Anatomy, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai – 600077, India.

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