Effectiveness of Posaconazole (POS) in an Inhalational Neutropenic Murine Model of Invasive Pulmonary Aspergillosis against Voriconazole Resistant (VCZ-R) Aspergillus flavus | Chapter 5 | Research Advances in Microbiology and Biotechnology Vol. 6

 This member discuss about the resentment of a laboratory-selected VCZ-R detach of A. flavus isolate (cyp51A mutation-K197N) and the efficacy of POS against this sequester were evaluated utilizing a neutropenic murine model of invasive pulmonary aspergillosis by determining the pulmonary fungal burden and mortality in miscellaneous groups of mice. . Invasive aspergillosis (IA) persists to be guide a high mortality in spite of timely and appropriate healing in immunocompromised patients.  Clinical and material isolates of Aspergillus species appearance reduced susceptibility to VCZ have happened reported. Mortality, in spite of therapy, remnants high, and drug fighting might partly give reason for treatment disappointments. In this study, we noted that azole-opposition in A. flavus is dependent on the position of specific mutations in cyp51A. Isolates of VCZ-R A. flavus that demonstrated the K197N metamorphosis, were resistant to VCZ, but kept susceptibility to POS. Hence POS resumes to be a valuable alternative for certain isolates of VCZ-R A. flavus.In this experimental model of VCZ-R A. flavus rodent infection, posaconazole illustrated superior effectiveness to that of VCZ in threatening fungal burden (p 0.05) and death (p 0.05). This study accompanied that POS can be a good alternative for some VCZ-R A. flavus strains.

Author(s) Details:

Suganthini Krishnan,
John D. Dingell VA Medical Center, 4646 John R St, Detroit, MI 48201, United States and Wayne State University, 42 W Warren Ave, Detroit, MI 48202, United States.

Jagdeesh Natesan,
Boston University, Boston, MA, United States.

Jessica L. Cutright,
Wayne State University, 42 W Warren Ave, Detroit, MI 48202, United States.

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