Evaluation of Antioxidant Potential and Pro-Inflammatory Enzymes Inhibitory Activity of Fractions and Macerate from Pandiaka angustifolia (vahl) Hepper | Chapter 1 | Novel Aspects on Pharmaceutical Research Vol. 6

 In established medicines of Burkina Faso, a sort of ailments are treated accompanying Pandiaka angustifolia (Vahl) Hepper, a shrub from the Amaranthaceae kin. Amaranthaceae is one of the offspring of plants that are frequently used to treat affliction. This investigation was made to evaluate the lipoxygenase and xanthine oxidase inhibitory potentials of hydroacetonic macerate and parts of Pandiaka angustifolia, as well as the amount of phenolics and flavonoids, antioxidant ability, and other possessions. The findings showed  the Dichloromethane Fraction (DCMF) own the best inhibitory action of lipoxygenase, a key enzyme complicated in inflammatory process accompanying 83.84±1.89% of inhibition, as regards Xanthine Oxidase (XO) restricting percentage, n-hexane part (n-HF) exhibited the chief percentage of restriction with 76.22 ± 4.78% at a concentration of 100µg/ml. Evaluation of the phenolic and flavonoid content of the parts and hydroacetonic macerate disclosed that the dichloromethane fraction (DCMF) had the chief phenolic and flavonoid content, respectively. This study illustrated that P. angustifolia's apolar fractions are a viable unrefined source for the situation of disorders associated with redness and oxidative stress.

Author(s) Details:

A. M. E. Thiombiano,
Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.

Hilou Adama,
Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.

Bangou Mindiédiba Jean,
Department of Biochemistry and Microbiology/ Training and Research Unit in Life and Earth Science, Nazi BONI University, Bobo-Dioulasso, Burkina Faso.

Bagora Bayala,
Centre de Recherche Biomoléculaire Pietro Annogoni, Saint Camille-CERBA/ LABIOGENE- Ouagadougou, Université de Ouagadougou, 03 BP 7021 Ouagadougou 03, Burkina Faso.

Ouattara Nabèrè,
Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.

Guenné Samson,
Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.

Meda Nâg-Tiero Roland,
Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.

Compaoré Moussa,
Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.

Kiendrébeogo Martin,

Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.

Millogo F. Jeanne,

Laboratory of Biology and Plants Ecology, UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.

Nacoulma O. Germaine,

Laboratory of Biochemistry and Applied Chemistry (LABIOCA), UFR/SVT, 09 BP 848 Ouagadougou 09, University of Ouagadougou, Burkina Faso.

Please see the link here: https://stm.bookpi.org/NAPR-V6/article/view/11355