Applicability of a New Modified Calcium Starch as Release Retarding Polymer: A Comparative Study | Chapter 10 | Novel Aspects on Pharmaceutical Research Vol. 6

 This phase evaluate the drug release retarding effectiveness of a newly modified vigor named calcium vigor, in comparison to famous polymers namely hydroxy propyl methyl hydrogen (HPMC), sodium carboxy methyl cellulose (sodium CMC), ethyl cellulose and olibanum paste. Controlled-release dosage forms have created significant progress in conditions of clinical efficacy and patient agreement. Drug release from the systems bear be at a asked rate, predictable and reproducible. Polymers, that are used as release retarding materials in the design of regulated-release dosage forms play a lively role in ruling the delivery of drug from these portion of drug or other consumable forms. Gliclazide (30 mg) matrix tablets were created utilizing calcium starch and the added polymers at a polymer content of 5%, and the tablets underwent experiment. All of the calcium starch- and other polymer-located matrix tablets moderately released gliclazide over a ending of 12 to 24 hours. The release mechanism each of the prepared matrix tablets was erect to follow non-fickian spread. The release of Gliclazide from the matrix tablets steal hydroxy propyl methyl cellulose, ethyl cellulose, sodium CMC, and olibanum wax was relatively smart, and it was finished in 12hrs. But forge tablets prepared accompanying calcium starch, gliclazide release was slow and spread over 24 hours. The drug release was comparatively rapid in the case of sodium CMC, olibanum wax, ethyl cellulose and HPMC (98%- 99%) and the release was achieved within 8 – 12 hours with these tablets. In contrast, calcium vigor caused the gliclazide release expected gradual and out of touch with reality over 24 hours.

Author(s) Details:

Sailaja Gunnam,
Gokaraju Rangaraju College of Pharmacy, Affiliated with Osmania University, Hyderabad – 500090, India.

Monika Nijhawan,
Gokaraju Rangaraju College of Pharmacy, Affiliated with Osmania University, Hyderabad – 500090, India.

Rajeswari Aleti,
Gokaraju Rangaraju College of Pharmacy, Affiliated with Osmania University, Hyderabad – 500090, India.

Please see the link here: https://stm.bookpi.org/NAPR-V6/article/view/11364

Estimation of Metformin Hydrochloride, Gliclazide and Pioglitazone Hydrochloride: A UDDD-HPTLC Densitometry Method Validation Study | Chapter 12 | Novel Aspects on Pharmaceutical Research Vol. 3

 A plain and new UDDD-HPTLC method has happened developed and justified for their estimation of MET, GLZ and PIO all-inclusive and combined dose dosage form. Metformin (MET) is chemically, 1-carbamimidamido-N-N-dimethyl- methanimidamide. It is an oral antagonistic-diabetic drug from the biguanide class. It is the first-line drug for the treatment of type-2 diabetes, specifically in overweight and corpulent people and those accompanying normal sort function and evidences suggest possibly the best choice for people as political whole with heart attack.The  chromatographic  separation  of  these  drugs  was  completed activity  on  precoated  TLC  plates  silica  gel  60F254by  two  mobile steps consisting of Ammonium Sulphate: Methanol: Acetonitrile: Water (4:3:2:1) for MET and PIO and Toluene: Ethyl Acetate: Formic Acid (6:4:0.5) for GLZ individually for ideal separation and good judgment. The densitometric detection and calculation were carried out at 237 nm for MET and 200 nm for GLZ and PIO. The confirmation parameters were rigidly followed as per the ICH directions.Chromatographic separation of the standard answer of MET, GLZ and was performed. Briefly, the spot of the standard answer was applied on TLC plates. The TLC plates were developed by uninterrupted ascending growth by using miscellaneous solvents in the way that acetone, benzene, chloroform, ethyl acetate, intoxicating and toluene. The linearity range was got at 3000-8000ng/spot, 360-960 ng/spot, 90-240 ng/spot for MET, GLZ and PIO with r2value>0.999. The different parameters to a degree precision, reproducibility, strength were efficiently obtained believable. The proposed arrangement was successfully used for simultaneous perseverance of MET, GLZ and PIO in the commercial expression.In simultaneous belief, the different opposition of drugs makes it more burdensome to develop and confirm any chromatographic method. In comparison to HPLC, the submitted UDDD-HPTLC method is novel, less high-priced, simpler, smart, and more flexible. This method can be secondhand for routine quality control study because it authorizes simultaneous guess of all API on a single TLC plate accompanying a single application.

Author(s) Details:

Rajesh Varade,
Pacific University, Udaipur, Rajasthan-313024, India.

Harsha Mishra,
Pacific University, Udaipur, Rajasthan-313024, India and K. J. Somaiya Institute of Engineering and Information Technology, Mumbai, Mh-400022, India.

Please see the link here: https://stm.bookpi.org/NAPR-V3/article/view/10887

Solid Dispersion of an Anti-Diabetic Drug with Block Co-Polymer for Enhancement of Aqueous Solubility, Dissolution and Bioavailability | Chapter 5 | Technological Innovation in Pharmaceutical Research Vol. 8

 Pre-formulation and formulation studies for the creation of solid dispersions with improved oral bioavailability are the focus of this study. Gliclazide (GLC), an oral hypoglycemic medication, has a low solubility in stomach fluid, a slow dissolving rate, and a wide range of bioavailability between individuals. The goal of this work was to use the lyophillisation process to create optimal solid dispersions (SD) of GLC with a hydrophilic carrier, such as poloxamer 407 (PXM), in order to improve the drug's aqueous solubility and therapeutic efficacy. The influence of polymer concentration on GLC solubility was investigated using a phase solubility research with increasing PXM concentrations (0.5 to 10% w/v). Physical mixing and lyophillisation (freeze drying) were used to make SDs of GLC and PXM in 1:1, 1:3, and 1:5w/w ratios, which were then tested for dissolving. On twelve healthy New Zealand rabbits, an in vivo comparison of optimised SD and GLC was undertaken. When compared to physical mixes and pure drug, the dissolution rate of GLC from lyophilized dispersions was significantly higher. In vivo experiments revealed that the pharmacokinetic properties of the optimised SD and pure GLC after oral administration were significantly different (P 0.05). The peak serum concentrations (Cmax) for the lyophilized SD and GLC were determined to be 3.010.42 g/mL and 2.27 0.39 g/mL, respectively, while the time required to attain the peak serum concentration (Tmax) for the optimised SD was much less (2.160.41) than for GLC (4.330.52). In an invivo test, the SD's relative bioavailability was reported to be 158.52 percent. These findings show that using a suitably hydrophilic carrier such as PXM to create SDs using the lyophillisation approach can significantly increase the solubility and in vitro dissolution of a lipophilic medication such as GLC. The proposed approach shows promising results in terms of gliclazide absorption and bioavailability after oral administration, and it can be used for other hydrophobic drug moities.

Author (s) Details

Farzana S. Bandarkar
Department of Pharmaceutics, Faculty of Pharmacy, Kuwait, University, Kuwait.

Ibrahim S. Khattab
Kuwait Saudi Pharmaceutical Industries Company, Kuwait.

View Book :- https://stm.bookpi.org/TIPR-V8/article/view/2208