The Role of Phenytoin for Treatment of Enterocutan Fistula in Wistar Rat| Chapter 3 | Current Overview on Disease and Health Research Vol. 11

 Introduction: Enterocutanean fistula (ECF) is a difficult intestinal question; even though willing closure happens 90% of moment of truth, it takes nearly 5 weeks. Phenytoin was guide faster pancreatic and enterocutaneous fistula composition. To purify the system of the restorative effect of phenytoin on ECF, animal research will make public.Methods: The width of the ECF, the number of fibroblasts, angiogenesis, the number (percentage) of collagen, the tickness of granulation fabric, and the number of lymphocytes were calculated in a randomized reserved trial equating the ECF of Wistar rats doctored accompanying a blend of depressed-measure phenytoin and source of nourishment C to phenytoin (oral and current) or source of nourishment C unique to a fake pill.Results: The width of the ECF was considerably (p< 0.05) weakened subsequently extreme-application phenytoin treatment and a merger of reduced-shot phenytoin and source of nourishment C. High-lot phenytoin or a alliance of reduced-measurement phenytoin and Vit C raised the number of fibroblasts, allotment or number of colagen, granulation tissue density, and angiogenesis while declining the number of lymphocytes (p 0.05).Conclusion: High-measurement phenytoin or depressed-dosage phenytoin linked accompanying source of nourishment C expedites ECF plug by increasing fibrosis, collagen, angiogenesis, and granulation fabric while declining lymphocytes .

Author(s) Details:

Sigit Adi Prasetyo,
Department of Surgery, Diponegoro Medical Faculty, Diponegoro University Semarang, Indonesia.

Victor Kurniawan,
Diponegoro University Semarang, Indonesia.

Budiman Irphan,
Diponegoro University Semarang, Indonesia.

Yohanes Sugiarto,
Diponegoro University Semarang, Indonesia.

Iwan Saragih,
Diponegoro University Semarang, Indonesia.

Gede Pambudi,
Diponegoro University Semarang, Indonesia.

Trilaksono Nugroho,
Department of Pharamacology, Diponegoro Medical Faculty, Diponegoro University Semarang, Indonesia.

. Hardian,
Department of Physiology, Diponegoro University Semarang, Indonesia.

. Hermawan,
Department of Pathology, Faculty of Medicine, Diponegoro University Semarang, Indonesia.

Ignatius Riwanto,
Department of Surgery, Diponegoro Medical Faculty, Diponegoro University Semarang, Indonesia.

Please see the link here: https://stm.bookpi.org/CODHR-V11/article/view/9286